VAV2 and RBBP6

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		VAV2	RBBP6
Gene Name		vav 2 guanine nucleotide exchange factor	retinoblastoma binding protein 6
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleoplasm Chromosome Nucleolus Cytoplasm Microtubule Organizing Center
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly(A) RNA Binding
	Biological Process	Angiogenesis Signal Transduction Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Regulation Of Gene Expression Cell Migration Lamellipodium Assembly Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	In Utero Embryonic Development Multicellular Organism Growth Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Somite Development
Pathways		Signaling by GPCR Axon guidance L1CAM interactions FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Rho GTPase cycle DAP12 signaling EPH-ephrin mediated repulsion of cells VEGFR2 mediated vascular permeability EPH-Ephrin signaling G alpha (12/13) signalling events Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Signalling by NGF DAP12 interactions Signal transduction by L1 Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling GPCR downstream signaling Signaling by VEGF NRAGE signals death through JNK Signaling by Rho GTPases GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Multiple sclerosis ( 20598377) vWF and FVIII levels ( 21810271)	Brain structure ( 20171287) Obesity-related traits ( 23251661)
Protein-Protein Interactions		62 interactors: ARIH1 BIRC6 BOD1L1 BRDT BZW1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 FNTA FUCA1 FYN GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MARCH7 MED21 MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	32 interactors: ACOT13 ANAPC16 APOH ASGR1 CAPZA2 CD81 ETS1 EVA1C FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 NDUFB9 NEK6 PIAS1 PLG RBP4 RPS14 SMN1 SPP1 TPT1 UBE2I UPF3B VAV2 WBSCR16 YBX1 ZBTB38 ZFYVE9
Entrez ID		7410	5930
HPRD ID		02694	02964
Ensembl ID		ENSG00000160293	ENSG00000122257
Uniprot IDs		P52735	Q7Z6E9
PDB IDs		2DLZ 2DM1 2LNW 2LNX	2C7H 2YSA 2YUR 3ZTG
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Response To Organic Substance Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Platelet Activation Innate Immune Response Regulation Of Cellular Protein Metabolic Process Cellular Protein Modification Process Cellular Metabolic Process Protein Metabolic Process Positive Regulation Of Viral Process Regulation Of Body Fluid Levels Wound Healing Immune Response Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Cell Activation Regulation Of Signal Transduction Response To Wounding Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Viral Process Positive Regulation Of Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Protein Ubiquitination Regulation Of Immune System Process Signal Transduction Regulation Of Intracellular Signal Transduction Chemotaxis Positive Regulation Of Homotypic Cell-cell Adhesion	Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Cellular Component Assembly Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Blood Coagulation Hemostasis Response To Wounding Response To External Stimulus Regulation Of Blood Coagulation Response To Stress Protein Sumoylation Regulation Of Wound Healing Mitotic Nuclear Division Regulation Of Body Fluid Levels Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Positive Regulation Of Blood Coagulation Regulation Of Immune System Process Immune System Process Reproductive Process Endocytosis Positive Regulation Of Coagulation Negative Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of SUMO Transferase Activity Protein Complex Assembly Positive Regulation Of Wound Healing Positive Regulation Of Metabolic Process Placenta Development Platelet Activation Cell Division Regulation Of Cell Proliferation Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Blood Coagulation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Labyrinthine Layer Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Differentiation Regulation Of Lipid Kinase Activity Negative Regulation Of Coagulation Glutamine Biosynthetic Process
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9	associates au competes core distal dwnn fos implicate initially iso3 isoform jun machinery mrnas multisubunit name poly polyadenylation precursors processing retinoblastoma rich rnas transcript untranslated unusual usage utrs
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9	associates au competes core distal dwnn fos implicate initially iso3 isoform jun machinery mrnas multisubunit name poly polyadenylation precursors processing retinoblastoma rich rnas transcript untranslated unusual usage utrs
Tagcloud (Intersection) ?