VAV2 and MED21

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		VAV2	MED21
Gene Name		vav 2 guanine nucleotide exchange factor	mediator complex subunit 21
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Mediator Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	Transcription Coactivator Activity DNA-directed RNA Polymerase Activity Protein Binding
	Biological Process	Angiogenesis Signal Transduction Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Regulation Of Gene Expression Cell Migration Lamellipodium Assembly Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Blastocyst Development Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Maintenance Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Signaling by GPCR Axon guidance L1CAM interactions FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Rho GTPase cycle DAP12 signaling EPH-ephrin mediated repulsion of cells VEGFR2 mediated vascular permeability EPH-Ephrin signaling G alpha (12/13) signalling events Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Signalling by NGF DAP12 interactions Signal transduction by L1 Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling GPCR downstream signaling Signaling by VEGF NRAGE signals death through JNK Signaling by Rho GTPases GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Multiple sclerosis ( 20598377) vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		62 interactors: ARIH1 BIRC6 BOD1L1 BRDT BZW1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 FNTA FUCA1 FYN GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MARCH7 MED21 MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	25 interactors: BLOC1S6 BRCA1 BTF3 CDK8 CDK9 ESR1 ESR2 HNF4A HTT MAGEB4 MED29 PCBD2 POLR2A SKP1 SSC5D TARBP2 TCEB3 TFG THRA THRB TP53 TRIM27 VAV2 ZNF655 ZSCAN1
Entrez ID		7410	9412
HPRD ID		02694	09156
Ensembl ID		ENSG00000160293	ENSG00000152944
Uniprot IDs		P52735	F5H872 Q13503
PDB IDs		2DLZ 2DM1 2LNW 2LNX
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Response To Organic Substance Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Platelet Activation Innate Immune Response Regulation Of Cellular Protein Metabolic Process Cellular Protein Modification Process Cellular Metabolic Process Protein Metabolic Process Positive Regulation Of Viral Process Regulation Of Body Fluid Levels Wound Healing Immune Response Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Cell Activation Regulation Of Signal Transduction Response To Wounding Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Viral Process Positive Regulation Of Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Protein Ubiquitination Regulation Of Immune System Process Signal Transduction Regulation Of Intracellular Signal Transduction Chemotaxis Positive Regulation Of Homotypic Cell-cell Adhesion	Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Cyclic Compound RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Gene Expression Gene Expression Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Response To Steroid Hormone Regulation Of Viral Process Positive Regulation Of Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Viral Process Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipid Female Courtship Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Secretion Response To Stimulus Rhythmic Process Cellular Response To Stimulus Mating
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9	accompanied beads blocking cadherin coactivator core defects differentiation drip drip205 facilitates glioma homolog hyperproliferation interacting keratinocyte keratinocytes med1 med10 mediator multisubunit newly oncogene promoting silencing subunit subunits vdr vitamin
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9	accompanied beads blocking cadherin coactivator core defects differentiation drip drip205 facilitates glioma homolog hyperproliferation interacting keratinocyte keratinocytes med1 med10 mediator multisubunit newly oncogene promoting silencing subunit subunits vdr vitamin
Tagcloud (Intersection) ?