VAV2 and CHMP3

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		VAV2	CHMP3
Description		vav guanine nucleotide exchange factor 2	charged multivesicular body protein 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Early Endosome Late Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylcholine Binding Identical Protein Binding Molecular Function Inhibitor Activity Ubiquitin-specific Protease Binding
	Biological Process	Angiogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Cell Projection Assembly Lamellipodium Assembly Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Xenobiotic Stimulus	Plasma Membrane Repair Autophagy Apoptotic Process Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Endosome To Lysosome Transport Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Positive Regulation Of Cytokinesis Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Suppression Of Viral Release By Host Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Regulation Of Endosome Size Protein Polymerization Cell Division Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Regulation Of Exosomal Secretion Regulation Of Early Endosome To Late Endosome Transport
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Azathioprine ADME	Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) vWF and FVIII levels ( 21810271)	Adult body size ( 32376654) Glomerular filtration rate in chronic kidney disease ( 26420894) Nicotine dependence symptom count ( 25555482)
Interacting Genes		67 interacting genes: AR ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 ERBB4 FNTA FUCA1 FYN GAB1 GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MET MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR PRRG4 RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	14 interacting genes: APP CHMP2A CHMP2B CHMP4A CHMP4B FBXO7 HSPA13 IGFBP7 RAB11A SMAD1 SMAD5 STAMBP TNPO3 VAV2
Entrez ID		7410	51652
HPRD ID		02694	15650
Ensembl ID		ENSG00000160293	ENSG00000115561
Uniprot IDs		P52735	Q9Y3E7
PDB IDs		2DLZ 2DM1 2LNW 2LNX 4ROJ 7RNV 7WFY	2GD5 2XZE 3FRT 3FRV 7ZCG 7ZCH
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Modification Process Peptidyl-tyrosine Phosphorylation Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion ERBB Signaling Pathway Protein Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Phosphotyrosine Residue Binding Protein Phosphorylation Positive Regulation Of Protein Localization To Membrane Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Protein Localization Phosphorylation Protein Modification By Small Protein Conjugation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Enzyme Binding Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Protein Ubiquitination Regulation Of Protein Localization To Membrane Kinase Activity Basal Plasma Membrane Positive Regulation Of Cell-cell Adhesion Protein Binding Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Protein Localization Regulation Of Receptor Signaling Pathway Via JAK-STAT Macromolecule Metabolic Process	Kinetochore Microtubule Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Multivesicular Body Mitotic Metaphase Chromosome Alignment Viral Budding From Plasma Membrane Lysosomal Membrane Organization Metaphase Chromosome Alignment Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Chromosome Localization Mitotic Cytokinetic Process Endosome Organization Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Late Endosome To Vacuole Transport Cytokinetic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Membrane Assembly Nuclear Pore Nucleus Organization Endosome Vesicle Fusion Organelle Membrane Fusion Regulation Of Organelle Assembly Endosomal Transport Membrane Coat Osteoblast Fate Commitment Plasma Membrane Organization Lysosomal Transport Cytosol Autophagy Organelle Fusion
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