VAV2 and EIF4G3

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		VAV2	EIF4G3
Gene Name		vav 2 guanine nucleotide exchange factor	eukaryotic translation initiation factor 4 gamma, 3
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	RNA Cap Binding Translation Initiation Factor Activity Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Angiogenesis Signal Transduction Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Regulation Of Gene Expression Cell Migration Lamellipodium Assembly Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Translational Initiation Regulation Of Translational Initiation Viral Process Cytokine-mediated Signaling Pathway
Pathways		Signaling by GPCR Axon guidance L1CAM interactions FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Rho GTPase cycle DAP12 signaling EPH-ephrin mediated repulsion of cells VEGFR2 mediated vascular permeability EPH-Ephrin signaling G alpha (12/13) signalling events Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Signalling by NGF DAP12 interactions Signal transduction by L1 Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling GPCR downstream signaling Signaling by VEGF NRAGE signals death through JNK Signaling by Rho GTPases GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation	ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS		Multiple sclerosis ( 20598377) vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		62 interactors: ARIH1 BIRC6 BOD1L1 BRDT BZW1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 FNTA FUCA1 FYN GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MARCH7 MED21 MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	7 interactors: CAMK1 EIF4A1 EIF4E LIG4 MKNK1 PABPC1 VAV2
Entrez ID		7410	8672
HPRD ID		02694	06802
Ensembl ID		ENSG00000160293	ENSG00000075151
Uniprot IDs		P52735	O43432 Q504Z1 Q59GJ0
PDB IDs		2DLZ 2DM1 2LNW 2LNX	1HU3
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Response To Organic Substance Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Platelet Activation Innate Immune Response Regulation Of Cellular Protein Metabolic Process Cellular Protein Modification Process Cellular Metabolic Process Protein Metabolic Process Positive Regulation Of Viral Process Regulation Of Body Fluid Levels Wound Healing Immune Response Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Cell Activation Regulation Of Signal Transduction Response To Wounding Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Viral Process Positive Regulation Of Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Protein Ubiquitination Regulation Of Immune System Process Signal Transduction Regulation Of Intracellular Signal Transduction Chemotaxis Positive Regulation Of Homotypic Cell-cell Adhesion	Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Translational Initiation Regulation Of Translation MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression DNA Ligation Involved In DNA Recombination MRNA Metabolic Process Viral Process RNA Processing Translation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Synapse Structural Plasticity Cellular Macromolecule Catabolic Process Lagging Strand Elongation Pro-B Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Apoptotic Process Establishment Of Integrated Proviral Latency Programmed Cell Death Cellular Response To Stimulus Nucleocytoplasmic Transport System Development Nuclear Transport Cell Death Death Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Cellular Protein Metabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Synapse Structural Plasticity Response To Organic Substance Lymphoid Progenitor Cell Differentiation Positive Regulation Of Protein Export From Nucleus DNA Ligation Apoptotic Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9	absent aminopeptidase anpep antigen autoregulatory controlling deaf1 deformed degrades diminished encodes fine histocompatibility ko lnscs lymph maintaining mhc nodes peripheral polysome profiling protease pta stromal t1d translation tuning
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9	absent aminopeptidase anpep antigen autoregulatory controlling deaf1 deformed degrades diminished encodes fine histocompatibility ko lnscs lymph maintaining mhc nodes peripheral polysome profiling protease pta stromal t1d translation tuning
Tagcloud (Intersection) ?