RBBP6 and EIF4ENIF1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		RBBP6	EIF4ENIF1
Description		RB binding protein 6, ubiquitin ligase	eukaryotic translation initiation factor 4E nuclear import factor 1
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GO Annotations	Cellular Component	Nucleus Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck Protein-containing Complex	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Nucleic Acid Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Kinase Binding
	Biological Process	In Utero Embryonic Development DNA Replication Regulation Of DNA Replication MRNA Processing Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Multicellular Organism Growth Embryonic Organ Development Somite Development	Translation Regulation Of Translation Protein Import Into Nucleus Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation MRNA Stabilization Nuclear Export Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Pathways		RHOBTB1 GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Brain structure ( 20171287) Chronotype ( 30696823) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Age-related hearing impairment ( 24939585) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		44 interacting genes: ACOT13 AGO2 ANAPC16 APOH ASGR1 CAPZA2 CASK CD81 CLK1 CPSF3 EIF4ENIF1 ETS1 EVA1C FAAP24 FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 MDM2 MIR19A MIR19B1 NDUFB9 NEK6 PIAS1 PLG RB1 RBP4 RCC1L RPS14 SMN1 SPP1 TFIP11 TP53 TPT1 UBE2I UPF3B VAV2 YBX1 ZBTB38 ZFYVE9	92 interacting genes: ALG13 ANKHD1 ANXA2 ATP5F1B ATXN1 BAG4 BCAS2 BYSL CDK6 CFAP206 CLASP1 CLK3 CPSF7 CTNNA1 CUL1 DAPK1 DDX1 DDX11 DDX28 DEF6 DHX37 DHX57 DST DTX2 EEF1G EFHC1 EHMT2 EIF3E EIF4E EIF4E2 ELAVL3 EXOSC7 FANCL FDPS FTSJ3 GOLGA4 HDGF HNRNPF HNRNPLL HOOK3 HSPA1A KPNA2 KRT19 KRT31 L3MBTL2 LLPH LMNA LUC7L MGAT5B MYO10 NOP9 NXF3 OIP5 PKP2 PNKP POLR2A PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAE1 RBBP6 RBFOX2 RBM22 RNF10 RPL15 RPL19 RPL26 RPL31 RPRD1B RPS21 RPS6 RPS7 SF3B3 SMAD3 SNRNP40 SNRPN SPAG5 SRBD1 SRSF8 SUPV3L1 TCHP TRAK2 TTC19 TUBA1A TXLNA USP2 WBP4 WTAP XRCC6
Entrez ID		5930	56478
HPRD ID		02964	10456
Ensembl ID		ENSG00000122257	ENSG00000184708
Uniprot IDs		Q7Z6E9	Q9NRA8
PDB IDs		2C7H 2YSA 2YUR 3ZTG 6E5X	5ANR 6F9W 6X2R
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Developmental Process PML Body Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Differentiation SUMO Transferase Activity Regulation Of Cell Cycle Phase Transition Cellular Response To Actinomycin D Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Negative Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Response To Actinomycin D Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Disordered Domain Specific Binding Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Muscle Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To UV-C Glial Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Locomotion Positive Regulation Of Catabolic Process Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Antibiotic Regulation Of Cell Cycle G1/S Phase Transition Ubiquitin Protein Ligase Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Migration Positive Regulation Of B Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing	RNA Binding RNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of RNA Splicing Nucleus Nucleolus Cytosolic Ribosome Ribonucleoprotein Complex Cytoplasm Translation RNA Splicing Structural Constituent Of Ribosome RRNA Processing Nuclear Speck Cytoplasmic Translation Helicase Activity RRNA Metabolic Process Catalytic Step 2 Spliceosome Centrosome MRNA Splicing, Via Spliceosome Protein Binding RNA Splicing, Via Transesterification Reactions Macromolecule Biosynthetic Process Cytoskeleton Preribosome, Small Subunit Precursor Ribonucleoprotein Complex Biogenesis RNA Helicase Activity Prp19 Complex Spliceosomal Complex MRNA Binding Ribosome Positive Regulation Of RNA Splicing RNA 3'-end Processing Regulation Of Neurogenesis Microtubule Cytoskeleton Organization MRNA Cap Binding Ubiquitin Protein Ligase Binding Cytosolic Large Ribosomal Subunit Microtubule Plus-end Microtubule Anchoring Chromosome Cytosol Structural Molecule Activity
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