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VAV2 and CCNO
Number of citations of the paper that reports this interaction (PMID
18654987
)
7
Data Source:
BioGRID
(two hybrid)
VAV2
CCNO
Gene Name
vav 2 guanine nucleotide exchange factor
cyclin O
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
Nucleoplasm
Cytoplasm
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
Metal Ion Binding
Uracil DNA N-glycosylase Activity
Biological Process
Angiogenesis
Signal Transduction
Small GTPase Mediated Signal Transduction
Axon Guidance
Blood Coagulation
Regulation Of Gene Expression
Cell Migration
Lamellipodium Assembly
Platelet Activation
Regulation Of Blood Coagulation
Positive Regulation Of Rho GTPase Activity
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Base-excision Repair
Cell Cycle
Cilium Assembly
Response To Drug
Cell Division
Multi-ciliated Epithelial Cell Differentiation
Pathways
Signaling by GPCR
Axon guidance
L1CAM interactions
FCERI mediated MAPK activation
VEGFA-VEGFR2 Pathway
Rho GTPase cycle
DAP12 signaling
EPH-ephrin mediated repulsion of cells
VEGFR2 mediated vascular permeability
EPH-Ephrin signaling
G alpha (12/13) signalling events
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Signalling by NGF
DAP12 interactions
Signal transduction by L1
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
GPCR downstream signaling
Signaling by VEGF
NRAGE signals death through JNK
Signaling by Rho GTPases
GPVI-mediated activation cascade
Fc epsilon receptor (FCERI) signaling
FCERI mediated Ca+2 mobilization
Platelet activation, signaling and aggregation
Base Excision Repair
Depyrimidination
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Removal of DNA patch containing abasic residue
Base-Excision Repair, AP Site Formation
Resolution of AP sites via the single-nucleotide replacement pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
Displacement of DNA glycosylase by APE1
Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Multiple sclerosis (
20598377
)
vWF and FVIII levels (
21810271
)
Protein-Protein Interactions
62 interactors:
ARIH1
BIRC6
BOD1L1
BRDT
BZW1
CBL
CBLB
CCNO
CCT2
CCT3
CD19
CD44
CEP170
CHMP3
CRCP
DCUN1D4
DNAJC21
EGFR
EIF4G3
EPHB2
ERBB2
ERBB3
FNTA
FUCA1
FYN
GAPVD1
GRB2
HNRNPF
HSPH1
IPO4
MARCH7
MED21
MRGBP
NCKAP5
NEK3
PHF10
PNMA1
POGZ
PPM1B
PRLR
RAC1
RAD23A
RBBP6
RHOA
RHOG
SERBP1
SF3A3
SH3BP2
SNW1
SOCS1
SRPK2
SRRT
ST13
STK24
SYK
TARBP2
TCP11
TOM1L1
TTN
UBE4B
USP38
VCPIP1
4 interactors:
ITSN1
PCNA
RPA2
VAV2
Entrez ID
7410
10309
HPRD ID
02694
06375
Ensembl ID
ENSG00000160293
ENSG00000152669
Uniprot IDs
P52735
P22674
PDB IDs
2DLZ
2DM1
2LNW
2LNX
Enriched GO Terms of Interacting Partners
?
Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Response To Fibroblast Growth Factor
Phosphatidylinositol-mediated Signaling
Cellular Response To Organic Substance
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Cellular Response To Growth Factor Stimulus
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Response To Organic Substance
Peptidyl-tyrosine Phosphorylation
Fc Receptor Signaling Pathway
Platelet Activation
Innate Immune Response
Regulation Of Cellular Protein Metabolic Process
Cellular Protein Modification Process
Cellular Metabolic Process
Protein Metabolic Process
Positive Regulation Of Viral Process
Regulation Of Body Fluid Levels
Wound Healing
Immune Response
Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Axon Guidance
Cell Activation
Regulation Of Signal Transduction
Response To Wounding
Regulation Of Signaling
Intracellular Signal Transduction
Regulation Of T Cell Activation
Viral Process
Positive Regulation Of Signal Transduction
Blood Coagulation
Cell Surface Receptor Signaling Pathway
Hemostasis
Protein Ubiquitination
Regulation Of Immune System Process
Signal Transduction
Regulation Of Intracellular Signal Transduction
Chemotaxis
Positive Regulation Of Homotypic Cell-cell Adhesion
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
Transcription-coupled Nucleotide-excision Repair
Mismatch Repair
Base-excision Repair
Telomere Maintenance
Nucleotide-excision Repair
Ephrin Receptor Signaling Pathway
DNA-dependent DNA Replication
Positive Regulation Of Deoxyribonuclease Activity
G1/S Transition Of Mitotic Cell Cycle
Leading Strand Elongation
Positive Regulation Of Hydrolase Activity
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
DNA Recombination
Positive Regulation Of Rho GTPase Activity
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Recombinase Assembly
Regulation Of Rho GTPase Activity
DNA Replication
Positive Regulation Of Catalytic Activity
Regulation Of Rho Protein Signal Transduction
Apoptotic Signaling Pathway
Axon Guidance
Translesion Synthesis
Positive Regulation Of Ras GTPase Activity
Regulation Of DNA Damage Checkpoint
Regulation Of Double-strand Break Repair Via Homologous Recombination
Axonogenesis
Regulation Of Ras GTPase Activity
Nucleotide-excision Repair, DNA Damage Removal
Axon Development
Cellular Response To Growth Factor Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Apoptotic Process
Postreplication Repair
Positive Regulation Of Programmed Cell Death
DNA Repair
Chemotaxis
Response To Growth Factor
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Regulation Of Catalytic Activity
Tagcloud
?
calm3
cblb
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
wilcoxon
yes
zfyve9
Tagcloud (Difference)
?
calm3
cblb
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
wilcoxon
yes
zfyve9
Tagcloud (Intersection)
?