RBBP6 and MAD2L2

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		RBBP6	MAD2L2
Gene Name		retinoblastoma binding protein 6	MAD2 mitotic arrest deficient-like 2 (yeast)
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Cytoplasm Microtubule Organizing Center	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Zeta DNA Polymerase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly(A) RNA Binding	RNA Polymerase II Activating Transcription Factor Binding Protein Binding JUN Kinase Binding
	Biological Process	In Utero Embryonic Development Multicellular Organism Growth Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Somite Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Growth DNA Repair Double-strand Break Repair Transcription, DNA-templated Actin Filament Organization Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Cell Division Negative Regulation Of APC-Cdc20 Complex Activity Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Translesion synthesis by Pol zeta DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template
Drugs
Diseases
GWAS		Brain structure ( 20171287) Obesity-related traits ( 23251661)	Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		32 interactors: ACOT13 ANAPC16 APOH ASGR1 CAPZA2 CD81 ETS1 EVA1C FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 NDUFB9 NEK6 PIAS1 PLG RBP4 RPS14 SMN1 SPP1 TPT1 UBE2I UPF3B VAV2 WBSCR16 YBX1 ZBTB38 ZFYVE9	22 interactors: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 ELK1 IKZF1 KCTD9 MAD2L1 POLDIP2 PRCC PRRC2A RBBP6 REL REV1 REV3L SFI1 TCF4 TRIM27 TRIP13 YY1AP1
Entrez ID		5930	10459
HPRD ID		02964	07246
Ensembl ID		ENSG00000122257	ENSG00000116670
Uniprot IDs		Q7Z6E9	Q9UI95
PDB IDs		2C7H 2YSA 2YUR 3ZTG	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Cellular Component Assembly Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Blood Coagulation Hemostasis Response To Wounding Response To External Stimulus Regulation Of Blood Coagulation Response To Stress Protein Sumoylation Regulation Of Wound Healing Mitotic Nuclear Division Regulation Of Body Fluid Levels Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Positive Regulation Of Blood Coagulation Regulation Of Immune System Process Immune System Process Reproductive Process Endocytosis Positive Regulation Of Coagulation Negative Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of SUMO Transferase Activity Protein Complex Assembly Positive Regulation Of Wound Healing Positive Regulation Of Metabolic Process Placenta Development Platelet Activation Cell Division Regulation Of Cell Proliferation Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Blood Coagulation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Labyrinthine Layer Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Differentiation Regulation Of Lipid Kinase Activity Negative Regulation Of Coagulation Glutamine Biosynthetic Process	Cell Cycle Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Process Extracellular Matrix Disassembly PMA-inducible Membrane Protein Ectodomain Proteolysis Mitotic Cell Cycle Error-prone Translesion Synthesis Response To Stress Regulation Of Meiosis Regulation Of Meiotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Collagen Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Translesion Synthesis Cell Cycle Checkpoint Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cell Adhesion Mediated By Integrin Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Division Multicellular Organismal Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Synapse Maturation Negative Regulation Of Transferase Activity Membrane Protein Ectodomain Proteolysis Regulation Of Synapse Maturation Postreplication Repair Cellular Response To Stress Proteolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Death Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Immune System Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Membrane Protein Proteolysis Tissue Development Negative Regulation Of Catalytic Activity Spindle Assembly Checkpoint Positive Regulation Of Protein Metabolic Process Innate Immune Response
Tagcloud ?		associates au competes core distal dwnn fos implicate initially iso3 isoform jun machinery mrnas multisubunit name poly polyadenylation precursors processing retinoblastoma rich rnas transcript untranslated unusual usage utrs	arrested cdk1 configuration eliminated fertility flexible g2 g9a glp h3k27me3 h3k9me2 infertile involves mad2b methyltransferases normally pgc pgcs primordial repressive reprogramming rev7 specification specified stably suppressive switch upregulate waves
Tagcloud (Difference) ?		associates au competes core distal dwnn fos implicate initially iso3 isoform jun machinery mrnas multisubunit name poly polyadenylation precursors processing retinoblastoma rich rnas transcript untranslated unusual usage utrs	arrested cdk1 configuration eliminated fertility flexible g2 g9a glp h3k27me3 h3k9me2 infertile involves mad2b methyltransferases normally pgc pgcs primordial repressive reprogramming rev7 specification specified stably suppressive switch upregulate waves
Tagcloud (Intersection) ?