VAV2 and USP38

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		VAV2	USP38
Description		vav guanine nucleotide exchange factor 2	ubiquitin specific peptidase 38
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Angiogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Cell Projection Assembly Lamellipodium Assembly Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Xenobiotic Stimulus	G1/S Transition Of Mitotic Cell Cycle Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Innate Immune Response Protein K48-linked Ubiquitination Antiviral Innate Immune Response Protein K33-linked Deubiquitination
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Azathioprine ADME
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) vWF and FVIII levels ( 21810271)	Adventurousness ( 30643258) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31451708) Malaria ( 31844061) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Risk-taking tendency (4-domain principal component model) ( 30643258) Severity of nausea and vomiting of pregnancy ( 29563502) Systolic blood pressure ( 27841878) Urate levels ( 31578528)
Interacting Genes		67 interacting genes: AR ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 ERBB4 FNTA FUCA1 FYN GAB1 GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MET MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR PRRG4 RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	3 interacting genes: HDAC1 UBC VAV2
Entrez ID		7410	84640
HPRD ID		02694	15635
Ensembl ID		ENSG00000160293	ENSG00000170185
Uniprot IDs		P52735	A0A804HIT0 B3KSB9 Q8NB14
PDB IDs		2DLZ 2DM1 2LNW 2LNX 4ROJ 7RNV 7WFY	4RXX
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Modification Process Peptidyl-tyrosine Phosphorylation Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion ERBB Signaling Pathway Protein Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Phosphotyrosine Residue Binding Protein Phosphorylation Positive Regulation Of Protein Localization To Membrane Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Protein Localization Phosphorylation Protein Modification By Small Protein Conjugation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Enzyme Binding Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Protein Ubiquitination Regulation Of Protein Localization To Membrane Kinase Activity Basal Plasma Membrane Positive Regulation Of Cell-cell Adhesion Protein Binding Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Protein Localization Regulation Of Receptor Signaling Pathway Via JAK-STAT Macromolecule Metabolic Process	Negative Regulation Of Myotube Differentiation Host-mediated Suppression Of Viral Transcription Hair Follicle Placode Formation Histone Deacetylase Activity Eyelid Development In Camera-type Eye Sin3-type Complex Response To Platelet-derived Growth Factor Krueppel-associated Box Domain Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Host-mediated Suppression Of Viral Proces Protein Deacetylation Protein Decrotonylase Activity NuRD Complex Protein Lysine Deacetylase Activity Histone Decrotonylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein Lysine Delactylase Activity Core Promoter Sequence-specific DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Cell Fate Specification Positive Regulation Of Oligodendrocyte Differentiation Fungiform Papilla Formation Protein Tag Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation NF-kappaB Binding Nucleosomal DNA Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Endoderm Development Host-mediated Perturbation Of Viral Transcription Anatomical Structure Formation Involved In Morphogenesis Regulation Of Androgen Receptor Signaling Pathway DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Lamellipodium Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone Deacetylase Complex Regulation Of Myotube Differentiation Oligodendrocyte Differentiation
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