VAV2 and ST13

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		VAV2	ST13
Gene Name		vav 2 guanine nucleotide exchange factor	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
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Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Cytoplasm Cytosol Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	Protein Binding Protein Domain Specific Binding Hsp70 Protein Binding Protein Binding, Bridging Protein Complex Binding DATP Binding Identical Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Angiogenesis Signal Transduction Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Regulation Of Gene Expression Cell Migration Lamellipodium Assembly Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Protein Folding Protein Homooligomerization Negative Regulation Of Protein Refolding Chaperone Cofactor-dependent Protein Refolding
Pathways		Signaling by GPCR Axon guidance L1CAM interactions FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Rho GTPase cycle DAP12 signaling EPH-ephrin mediated repulsion of cells VEGFR2 mediated vascular permeability EPH-Ephrin signaling G alpha (12/13) signalling events Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Signalling by NGF DAP12 interactions Signal transduction by L1 Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling GPCR downstream signaling Signaling by VEGF NRAGE signals death through JNK Signaling by Rho GTPases GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Multiple sclerosis ( 20598377) vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		62 interactors: ARIH1 BIRC6 BOD1L1 BRDT BZW1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 FNTA FUCA1 FYN GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MARCH7 MED21 MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	18 interactors: ALB APOE ASF1A CD101 CDC42 CTRC CXCR2 F2 HSP90AA1 HSPA1A HSPA4 HSPA8 NOS3 OLFM2 PSEN1 SMAD2 TTR VAV2
Entrez ID		7410	6767
HPRD ID		02694	08426
Ensembl ID		ENSG00000160293	ENSG00000100380
Uniprot IDs		P52735	B4E0U6 P50502 Q0IJ56
PDB IDs		2DLZ 2DM1 2LNW 2LNX	1UZS
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Response To Organic Substance Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Platelet Activation Innate Immune Response Regulation Of Cellular Protein Metabolic Process Cellular Protein Modification Process Cellular Metabolic Process Protein Metabolic Process Positive Regulation Of Viral Process Regulation Of Body Fluid Levels Wound Healing Immune Response Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Cell Activation Regulation Of Signal Transduction Response To Wounding Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Viral Process Positive Regulation Of Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Protein Ubiquitination Regulation Of Immune System Process Signal Transduction Regulation Of Intracellular Signal Transduction Chemotaxis Positive Regulation Of Homotypic Cell-cell Adhesion	Response To External Stimulus Response To Stress Locomotion Negative Regulation Of Platelet Activation Protein Refolding Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Heat Regulation Of Cellular Response To Heat Cellular Response To Stimulus Regulation Of Platelet Activation Positive Regulation Of Immune System Process Anatomical Structure Morphogenesis Regulation Of Wound Healing Response To Unfolded Protein Response To Stimulus Protein Import Into Mitochondrial Outer Membrane Cellular Component Assembly Regulation Of Nitric-oxide Synthase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Vesicle-mediated Transport Regulation Of Apoptotic Process Establishment Of Localization In Cell Movement Of Cell Or Subcellular Component Endocytosis Regulation Of Cell Death Response To Wounding Negative Regulation Of Blood Coagulation Response To Temperature Stimulus Blood Coagulation Negative Regulation Of Coagulation Hemostasis Cellular Response To Heat Negative Regulation Of Wound Healing Regulation Of Cell Morphogenesis Cell Communication Cellular Localization Cell Migration Cell Surface Receptor Signaling Pathway Cell Development Regulation Of Immune System Process Regulation Of Oxidoreductase Activity Secretion By Cell Cardiovascular System Development Anatomical Structure Development Blood Vessel Development Transport Cell Motility Vasculature Development
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9	carbapenemase centre cpe disseminated dublin ecdc encountered endemic enterobacteriaceae graded implementing intermittent internationally ireland irish klebsiella november outbreak oxa persisted pneumoniae producing pulsed referral sixteen st221 strict typing wards
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9	carbapenemase centre cpe disseminated dublin ecdc encountered endemic enterobacteriaceae graded implementing intermittent internationally ireland irish klebsiella november outbreak oxa persisted pneumoniae producing pulsed referral sixteen st221 strict typing wards
Tagcloud (Intersection) ?