VAV2 and VCPIP1

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		VAV2	VCPIP1
Description		vav guanine nucleotide exchange factor 2	valosin containing protein interacting protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Stack
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Angiogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Cell Projection Assembly Lamellipodium Assembly Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Xenobiotic Stimulus	DNA Repair Proteolysis DNA Damage Response Golgi Organization Endoplasmic Reticulum Membrane Fusion Protein Ubiquitination Protein Deubiquitination Protein K11-linked Deubiquitination Protein K48-linked Deubiquitination Golgi Reassembly Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Azathioprine ADME	Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) vWF and FVIII levels ( 21810271)
Interacting Genes		67 interacting genes: AR ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 ERBB4 FNTA FUCA1 FYN GAB1 GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MET MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR PRRG4 RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	11 interacting genes: FCHSD2 GSK3A HUNK SMAD9 SNTG2 SPRTN STX5 UBC VAV2 VCP WAC
Entrez ID		7410	80124
HPRD ID		02694	15645
Ensembl ID		ENSG00000160293	ENSG00000175073
Uniprot IDs		P52735	Q96JH7
PDB IDs		2DLZ 2DM1 2LNW 2LNX 4ROJ 7RNV 7WFY	8YKA
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Modification Process Peptidyl-tyrosine Phosphorylation Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion ERBB Signaling Pathway Protein Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Phosphotyrosine Residue Binding Protein Phosphorylation Positive Regulation Of Protein Localization To Membrane Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Protein Localization Phosphorylation Protein Modification By Small Protein Conjugation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Enzyme Binding Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Protein Ubiquitination Regulation Of Protein Localization To Membrane Kinase Activity Basal Plasma Membrane Positive Regulation Of Cell-cell Adhesion Protein Binding Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Protein Localization Regulation Of Receptor Signaling Pathway Via JAK-STAT Macromolecule Metabolic Process	Protein-DNA Covalent Cross-linking Repair Positive Regulation Of Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Translesion Synthesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Postreplication Repair Polyubiquitin Modification-dependent Protein Binding DNA Synthesis Involved In DNA Repair Interstrand Cross-link Repair Regulation Of Post-translational Protein Modification Negative Regulation Of UDP-glucose Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Stereocilium Shaft Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Organelle Disassembly VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination DNA Biosynthetic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Cytoplasm Protein Quality Control BAT3 Complex Binding Syntrophin Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Signal Transduction Positive Regulation Of Protein Deubiquitination Neuroligin Family Protein Binding Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Viral Process
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