RBBP6 and APOH

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		RBBP6	APOH
Description		RB binding protein 6, ubiquitin ligase	apolipoprotein H
Image
GO Annotations	Cellular Component	Nucleus Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck Protein-containing Complex	Extracellular Region Extracellular Space Cell Surface Platelet Dense Granule Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Lipase Binding Identical Protein Binding Lipoprotein Lipase Activator Activity
	Biological Process	In Utero Embryonic Development DNA Replication Regulation Of DNA Replication MRNA Processing Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Multicellular Organism Growth Embryonic Organ Development Somite Development	Negative Regulation Of Endothelial Cell Proliferation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Myeloid Cell Apoptotic Process Triglyceride Transport Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis Positive Regulation Of Triglyceride Metabolic Process
Pathways		RHOBTB1 GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Platelet degranulation
Drugs			LJP 1082 Copper
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Brain structure ( 20171287) Chronotype ( 30696823) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Activated partial thromboplastin time ( 29403010) Alanine aminotransferase levels ( 34315874) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Brain morphology (MOSTest) ( 32665545) Cardiometabolic and hematological traits ( 27668658) Coronary artery disease ( 29212778) Creatine kinase levels ( 29403010) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Presence of antiphospholipid antibodies ( 27098658) Systolic blood pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531)
Interacting Genes		44 interacting genes: ACOT13 AGO2 ANAPC16 APOH ASGR1 CAPZA2 CASK CD81 CLK1 CPSF3 EIF4ENIF1 ETS1 EVA1C FAAP24 FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 MDM2 MIR19A MIR19B1 NDUFB9 NEK6 PIAS1 PLG RB1 RBP4 RCC1L RPS14 SMN1 SPP1 TFIP11 TP53 TPT1 UBE2I UPF3B VAV2 YBX1 ZBTB38 ZFYVE9	14 interacting genes: AKT1 ANXA2 CDC42 CLEC4G F10 F12 GEM GRB2 LPA LRP2 LRP8 OGT PLG RBBP6
Entrez ID		5930	350
HPRD ID		02964	00728
Ensembl ID		ENSG00000122257	ENSG00000091583
Uniprot IDs		Q7Z6E9	A0A384NKM6 P02749
PDB IDs		2C7H 2YSA 2YUR 3ZTG 6E5X	1C1Z 1G4F 1G4G 1QUB 2KRI 3OP8 4JHS 6V06 6V08 6V09 6XSD 6XST 7JIK 7KG4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Developmental Process PML Body Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Differentiation SUMO Transferase Activity Regulation Of Cell Cycle Phase Transition Cellular Response To Actinomycin D Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Negative Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Response To Actinomycin D Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Disordered Domain Specific Binding Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Muscle Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To UV-C Glial Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Locomotion Positive Regulation Of Catabolic Process Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Antibiotic Regulation Of Cell Cycle G1/S Phase Transition Ubiquitin Protein Ligase Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Migration Positive Regulation Of B Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing	Fibrinolysis Apolipoprotein Binding Proteolysis Serine-type Peptidase Activity Positive Regulation Of Fibrinolysis Plasma Membrane Serine-type Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Proteolysis Positive Regulation Of Multicellular Organismal Process Regulation Of Protein Maturation Positive Regulation Of Plasminogen Activation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Positive Regulation Of TOR Signaling Glutamatergic Synapse Regulation Of Body Fluid Levels Low-density Lipoprotein Particle Receptor Activity Regulation Of Cell Migration Regulation Of Synapse Organization Regulation Of Plasminogen Activation Calcium Ion Binding Coagulation Blood Coagulation Regulation Of Fibrinolysis Regulation Of Cell Motility Hemostasis Protein Maturation Regulation Of Locomotion Regulation Of Multicellular Organismal Process Labyrinthine Layer Blood Vessel Development External Side Of Plasma Membrane Regulation Of Proteolysis Regulation Of Postsynapse Organization Regulation Of Protein Catabolic Process Regulation Of Wound Healing Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Spindle Midzone Positive Regulation Of Blood Coagulation Cargo Receptor Activity Blood Vessel Development Regulation Of TOR Signaling Positive Regulation Of Coagulation Embryonic Organ Development Placenta Blood Vessel Development Regulation Of Cell Adhesion
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