RBBP6 and RBP4

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		RBBP6	RBP4
Description		RB binding protein 6, ubiquitin ligase	retinol binding protein 4
Image
GO Annotations	Cellular Component	Nucleus Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck Protein-containing Complex	Extracellular Region Extracellular Space Protein-containing Complex Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Retinoid Binding Protein Binding Retinal Binding Retinol Binding Retinol Transmembrane Transporter Activity Protein-containing Complex Binding Molecular Carrier Activity
	Biological Process	In Utero Embryonic Development DNA Replication Regulation Of DNA Replication MRNA Processing Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Multicellular Organism Growth Embryonic Organ Development Somite Development	Retinoid Metabolic Process Eye Development Positive Regulation Of Immunoglobulin Production Gluconeogenesis Spermatogenesis Heart Development Visual Perception Phototransduction, Visible Light Male Gonad Development Response To Xenobiotic Stimulus Response To Muscle Activity Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Response To Insulin Retinol Transport Retinol Metabolic Process Retinal Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Detection Of Light Stimulus Involved In Visual Perception Retina Development In Camera-type Eye Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation Vitamin A Import Into Cell
Pathways		RHOBTB1 GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation	The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport Defective visual phototransduction due to STRA6 loss of function
Drugs			Tretinoin
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Brain structure ( 20171287) Chronotype ( 30696823) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Blood protein levels ( 30072576) Optic disc area ( 31798171) Retinol levels ( 21878437)
Interacting Genes		44 interacting genes: ACOT13 AGO2 ANAPC16 APOH ASGR1 CAPZA2 CASK CD81 CLK1 CPSF3 EIF4ENIF1 ETS1 EVA1C FAAP24 FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 MDM2 MIR19A MIR19B1 NDUFB9 NEK6 PIAS1 PLG RB1 RBP4 RCC1L RPS14 SMN1 SPP1 TFIP11 TP53 TPT1 UBE2I UPF3B VAV2 YBX1 ZBTB38 ZFYVE9	7 interacting genes: ALB GRB2 LAMTOR5 RBBP6 RIPPLY3 RPE65 TTR
Entrez ID		5930	5950
HPRD ID		02964	01580
Ensembl ID		ENSG00000122257	ENSG00000138207
Uniprot IDs		Q7Z6E9	P02753 Q5VY30
PDB IDs		2C7H 2YSA 2YUR 3ZTG 6E5X	1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB 6QBA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Developmental Process PML Body Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Differentiation SUMO Transferase Activity Regulation Of Cell Cycle Phase Transition Cellular Response To Actinomycin D Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Negative Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Response To Actinomycin D Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Disordered Domain Specific Binding Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Muscle Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To UV-C Glial Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Locomotion Positive Regulation Of Catabolic Process Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Antibiotic Regulation Of Cell Cycle G1/S Phase Transition Ubiquitin Protein Ligase Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Migration Positive Regulation Of B Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing	Protein-containing Complex Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Guanyl-nucleotide Exchange Factor Adaptor Activity Response To Radiation Grb2-EGFR Complex Terpenoid Metabolic Process All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity Retinoid Metabolic Process All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Zeaxanthin Biosynthetic Process Retinol Isomerase Activity Diterpenoid Metabolic Process Xanthophyll Metabolic Process Detection Of Light Stimulus Negative Regulation Of Skeletal Muscle Tissue Growth Isoprenoid Metabolic Process Carotenoid Metabolic Process Beta-carotene 15,15'-dioxygenase Activity Detection Of Abiotic Stimulus Negative Regulation Of Glomerular Filtration Ragulator Complex Neurotrophin TRKA Receptor Binding Vitamin A Metabolic Process Regulation Of Skeletal Muscle Tissue Growth
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