RBBP6 and RBP4

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		RBBP6	RBP4
Gene Name		retinoblastoma binding protein 6	retinol binding protein 4, plasma
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Cytoplasm Microtubule Organizing Center	Extracellular Region Extracellular Space Cytosol Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly(A) RNA Binding	Protein Binding Retinal Binding Retinol Binding Retinol Transporter Activity Protein Heterodimerization Activity
	Biological Process	In Utero Embryonic Development Multicellular Organism Growth Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Somite Development	Retinoid Metabolic Process Eye Development Gluconeogenesis Spermatogenesis Heart Development Phototransduction, Visible Light Male Gonad Development Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Response To Insulin Retinol Transport Retinol Metabolic Process Retinal Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Detection Of Light Stimulus Involved In Visual Perception Positive Regulation Of Immunoglobulin Secretion Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation
Pathways			Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Retinoid cycle disease events Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Brain structure ( 20171287) Obesity-related traits ( 23251661)	Retinol levels ( 21878437)
Protein-Protein Interactions		32 interactors: ACOT13 ANAPC16 APOH ASGR1 CAPZA2 CD81 ETS1 EVA1C FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 NDUFB9 NEK6 PIAS1 PLG RBP4 RPS14 SMN1 SPP1 TPT1 UBE2I UPF3B VAV2 WBSCR16 YBX1 ZBTB38 ZFYVE9	5 interactors: ALB GRB2 RBBP6 RPE65 TTR
Entrez ID		5930	5950
HPRD ID		02964	01580
Ensembl ID		ENSG00000122257	ENSG00000138207
Uniprot IDs		Q7Z6E9	P02753
PDB IDs		2C7H 2YSA 2YUR 3ZTG	1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Cellular Component Assembly Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Blood Coagulation Hemostasis Response To Wounding Response To External Stimulus Regulation Of Blood Coagulation Response To Stress Protein Sumoylation Regulation Of Wound Healing Mitotic Nuclear Division Regulation Of Body Fluid Levels Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Positive Regulation Of Blood Coagulation Regulation Of Immune System Process Immune System Process Reproductive Process Endocytosis Positive Regulation Of Coagulation Negative Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of SUMO Transferase Activity Protein Complex Assembly Positive Regulation Of Wound Healing Positive Regulation Of Metabolic Process Placenta Development Platelet Activation Cell Division Regulation Of Cell Proliferation Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Blood Coagulation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Labyrinthine Layer Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Differentiation Regulation Of Lipid Kinase Activity Negative Regulation Of Coagulation Glutamine Biosynthetic Process	Retinol Metabolic Process Retina Homeostasis Response To Radiation Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Response To External Stimulus Detection Of Light Stimulus Isoprenoid Metabolic Process Insulin Receptor Signaling Pathway Maintenance Of Mitochondrion Location Detection Of Abiotic Stimulus Hormone Metabolic Process Tissue Homeostasis Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Platelet Activation Cellular Response To Insulin Stimulus Response To Abiotic Stimulus Multicellular Organismal Homeostasis Regulation Of Rhodopsin Gene Expression Thyroid Hormone Transport Regulation Of Hormone Levels Lipid Metabolic Process Response To Insulin Cellular Response To Peptide Hormone Stimulus Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Vitamin A Metabolic Process Cellular Response To Peptide Response To Light Stimulus Alcohol Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Receptor-mediated Endocytosis Sodium-independent Organic Anion Transport Cellular Response To Electrical Stimulus Blood Coagulation Hemostasis Retinal Metabolic Process Detection Of Light Stimulus Involved In Visual Perception Tissue Development Response To Peptide Hormone Establishment Of Epithelial Cell Polarity Regulation Of Circadian Sleep/wake Cycle, Sleep Cellular Response To Organonitrogen Compound Embryonic Organ Development Response To Peptide Positive Regulation Of Circadian Rhythm
Tagcloud ?		associates au competes core distal dwnn fos implicate initially iso3 isoform jun machinery mrnas multisubunit name poly polyadenylation precursors processing retinoblastoma rich rnas transcript untranslated unusual usage utrs	acyltransferase cas9 conjunction crispr drives editing encodes es h3k27 kat3b kidneys lecithin lrat marks promoters ra rargamma retinol rxralpha stra6 stra6l stra6s suz12 transcribed transcript trimethylation usage vad vitamin
Tagcloud (Difference) ?		associates au competes core distal dwnn fos implicate initially iso3 isoform jun machinery mrnas multisubunit name poly polyadenylation precursors processing retinoblastoma rich rnas untranslated unusual utrs	acyltransferase cas9 conjunction crispr drives editing encodes es h3k27 kat3b kidneys lecithin lrat marks promoters ra rargamma retinol rxralpha stra6 stra6l stra6s suz12 transcribed trimethylation vad vitamin
Tagcloud (Intersection) ?		transcript usage