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RBBP6 and VAV2
Number of citations of the paper that reports this interaction (PubMedID
18654987
)
0
Data Source:
BioGRID
(two hybrid)
RBBP6
VAV2
Description
RB binding protein 6, ubiquitin ligase
vav guanine nucleotide exchange factor 2
Image
GO Annotations
Cellular Component
Nucleus
Chromosome
Nucleolus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Nuclear Speck
Protein-containing Complex
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
Nucleic Acid Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Protein Kinase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Phosphotyrosine Residue Binding
Guanyl-nucleotide Exchange Factor Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Biological Process
In Utero Embryonic Development
DNA Replication
Regulation Of DNA Replication
MRNA Processing
Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response
Protein Ubiquitination
Multicellular Organism Growth
Embryonic Organ Development
Somite Development
Angiogenesis
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Signal Transduction
Small GTPase-mediated Signal Transduction
Regulation Of Cell Size
Response To Xenobiotic Stimulus
Cell Migration
Cell Projection Assembly
Lamellipodium Assembly
Platelet Activation
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Xenobiotic Stimulus
Pathways
RHOBTB1 GTPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
GPVI-mediated activation cascade
GPVI-mediated activation cascade
NRAGE signals death through JNK
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Signal transduction by L1
VEGFR2 mediated vascular permeability
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
RAC3 GTPase cycle
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Azathioprine ADME
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Body mass index (
28892062
)
Body size at age 10 (
32376654
)
Brain structure (
20171287
)
Chronotype (
30696823
)
Low hand grip strength (60 years and older) (EWGSOP) (
33510174
)
Obesity-related traits (
23251661
)
Pulse pressure (
27841878
)
Systolic blood pressure (
27841878
)
Central corneal thickness (
29760442
)
Corneal astigmatism (
30306274
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Hematocrit (
27863252
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Multiple sclerosis (
20598377
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Red blood cell count (
32888494
)
vWF and FVIII levels (
21810271
)
Interacting Genes
44 interacting genes:
ACOT13
AGO2
ANAPC16
APOH
ASGR1
CAPZA2
CASK
CD81
CLK1
CPSF3
EIF4ENIF1
ETS1
EVA1C
FAAP24
FBXO7
GLUL
GRB2
HP
KHDRBS3
LINC00305
LRCH4
MAD2L2
MDM2
MIR19A
MIR19B1
NDUFB9
NEK6
PIAS1
PLG
RB1
RBP4
RCC1L
RPS14
SMN1
SPP1
TFIP11
TP53
TPT1
UBE2I
UPF3B
VAV2
YBX1
ZBTB38
ZFYVE9
67 interacting genes:
AR
ARIH1
BIRC6
BOD1L1
BRDT
BZW1
CAV1
CBL
CBLB
CCNO
CCT2
CCT3
CD19
CD44
CEP170
CHMP3
CRCP
DCUN1D4
DNAJC21
EGFR
EIF4G3
EPHB2
ERBB2
ERBB3
ERBB4
FNTA
FUCA1
FYN
GAB1
GAPVD1
GRB2
HNRNPF
HSPH1
IPO4
MED21
MET
MRGBP
NCKAP5
NEK3
PHF10
PNMA1
POGZ
PPM1B
PRLR
PRRG4
RAC1
RAD23A
RBBP6
RHOA
RHOG
SERBP1
SF3A3
SH3BP2
SNW1
SOCS1
SRPK2
SRRT
ST13
STK24
SYK
TARBP2
TCP11
TOM1L1
TTN
UBE4B
USP38
VCPIP1
Entrez ID
5930
7410
HPRD ID
02964
02694
Ensembl ID
ENSG00000122257
ENSG00000160293
Uniprot IDs
Q7Z6E9
P52735
PDB IDs
2C7H
2YSA
2YUR
3ZTG
6E5X
2DLZ
2DM1
2LNW
2LNX
4ROJ
7RNV
7WFY
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Developmental Process
PML Body
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Developmental Process
Regulation Of Cell Differentiation
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Differentiation
SUMO Transferase Activity
Regulation Of Cell Cycle Phase Transition
Cellular Response To Actinomycin D
Regulation Of MRNA Metabolic Process
Protein Domain Specific Binding
Negative Regulation Of Multicellular Organismal Process
Positive Regulation Of RNA Metabolic Process
Nucleoplasm
Response To Actinomycin D
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition
Disordered Domain Specific Binding
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Metabolic Process
Regulation Of Muscle Cell Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cellular Response To UV-C
Glial Cell Apoptotic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Locomotion
Positive Regulation Of Catabolic Process
Negative Regulation Of Matrix Metallopeptidase Secretion
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Antibiotic
Regulation Of Cell Cycle G1/S Phase Transition
Ubiquitin Protein Ligase Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Protein Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Regulation Of MRNA Stability
Regulation Of Endothelial Cell Migration
Regulation Of Metabolic Process
Regulation Of Immune System Process
Regulation Of Cell Migration
Positive Regulation Of B Cell Receptor Signaling Pathway
Regulation Of Multicellular Organismal Development
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of RNA Stability
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of MRNA Catabolic Process
MiRNA-mediated Post-transcriptional Gene Silencing
Protein Tyrosine Kinase Activity
Protein Modification Process
Peptidyl-tyrosine Phosphorylation
Regulation Of Lymphocyte Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cytosol
Epidermal Growth Factor Receptor Signaling Pathway
Protein Kinase Binding
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Cell Adhesion
ERBB Signaling Pathway
Protein Kinase Activity
Positive Regulation Of Metabolic Process
Positive Regulation Of Lymphocyte Activation
Regulation Of Cellular Localization
Phosphotyrosine Residue Binding
Protein Phosphorylation
Positive Regulation Of Protein Localization To Membrane
Regulation Of Cell Activation
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Leukocyte Cell-cell Adhesion
ERBB2 Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Protein Modification Process
Regulation Of Protein Localization
Phosphorylation
Protein Modification By Small Protein Conjugation
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Positive Regulation Of Protein Metabolic Process
Protein Metabolic Process
Enzyme Binding
Intracellular Signal Transduction
Positive Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Protein Ubiquitination
Regulation Of Protein Localization To Membrane
Kinase Activity
Basal Plasma Membrane
Positive Regulation Of Cell-cell Adhesion
Protein Binding
Regulation Of Protein Modification Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of T Cell Activation
Positive Regulation Of Protein Localization
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Macromolecule Metabolic Process
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