VAV2 and PPM1B

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		VAV2	PPM1B
Description		vav guanine nucleotide exchange factor 2	protein phosphatase, Mg2+/Mn2+ dependent 1B
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleolus Cytoplasm Cytosol Membrane
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Magnesium Ion Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Manganese Ion Binding Cation Binding Metal Ion Binding
	Biological Process	Angiogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Cell Projection Assembly Lamellipodium Assembly Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Xenobiotic Stimulus	Protein Dephosphorylation N-terminal Protein Myristoylation Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Defense Response To Virus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Azathioprine ADME	ISG15 antiviral mechanism ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) vWF and FVIII levels ( 21810271)	Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Height ( 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		67 interacting genes: AR ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 ERBB4 FNTA FUCA1 FYN GAB1 GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MET MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR PRRG4 RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	21 interacting genes: AATK CDK2 CDK6 ECHS1 EGFR ERBB3 ERBB4 IKBKB IKBKG KDR MAD2L2 MAP3K7 MSN MYL7 PPARG PTK7 ROR1 ROR2 RYK SIRPA VAV2
Entrez ID		7410	5495
HPRD ID		02694	04796
Ensembl ID		ENSG00000160293	ENSG00000138032
Uniprot IDs		P52735	O75688
PDB IDs		2DLZ 2DM1 2LNW 2LNX 4ROJ 7RNV 7WFY	2P8E
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Modification Process Peptidyl-tyrosine Phosphorylation Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion ERBB Signaling Pathway Protein Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Phosphotyrosine Residue Binding Protein Phosphorylation Positive Regulation Of Protein Localization To Membrane Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Protein Localization Phosphorylation Protein Modification By Small Protein Conjugation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Enzyme Binding Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Protein Ubiquitination Regulation Of Protein Localization To Membrane Kinase Activity Basal Plasma Membrane Positive Regulation Of Cell-cell Adhesion Protein Binding Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Protein Localization Regulation Of Receptor Signaling Pathway Via JAK-STAT Macromolecule Metabolic Process	Protein Kinase Activity Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity ATP Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Coreceptor Activity Transferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleotide Binding Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Locomotion ERBB2 Signaling Pathway Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Linear Polyubiquitin Binding Regulation Of Epithelial Cell Proliferation Wnt-protein Binding Phosphorylation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Histone Kinase Activity Regulation Of Cell Motility Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction IkappaB Kinase Complex Positive Regulation Of Phosphate Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction
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