NEK3 and VAV1

Number of citations of the paper that reports this interaction (PMID 15618286)
15

Data Source:
HPRD (in vivo)

		NEK3	VAV1
Gene Name		NIMA-related kinase 3	vav 1 guanine nucleotide exchange factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Axon	Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding
	Biological Process	Protein Phosphorylation Mitotic Nuclear Division Cell Division	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Rac GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Positive Regulation Of Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Small GTPase Mediated Signal Transduction Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins Signaling by VEGF Signaling by Rho GTPases Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling VEGFA-VEGFR2 Pathway Rho GTPase cycle PI3K events in ERBB2 signaling Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Regulation of signaling by CBL G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway Signaling by FGFR NRAGE signals death through JNK GPVI-mediated activation cascade FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS			Periodontitis ( 23459936)
Protein-Protein Interactions		6 interactors: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2	77 interactors: ABL1 ACTA1 AOC3 ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 EZH2 FGFR1 FYN GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 LMNA MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX
Entrez ID		4752	7409
HPRD ID		04954	01284
Ensembl ID		ENSG00000136098	ENSG00000141968
Uniprot IDs		P51956 Q6ZN64	B2R8B5 P15498 Q96D37
PDB IDs			2CRH 2LCT 2MC1 2ROR 3BJI 3KY9
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Activation Of JAK2 Kinase Activity Immune System Process Prolactin Signaling Pathway Platelet Activation Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Rho GTPase Activity Phagocytosis Activation Of Janus Kinase Activity Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity T Cell Aggregation Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Prostate Gland Growth Lymphocyte Activation Fructose 2,6-bisphosphate Metabolic Process Blood Coagulation Positive Regulation Of Catalytic Activity Mammary Gland Epithelial Cell Differentiation Hemostasis Positive Regulation Of Ras GTPase Activity Regulation Of Cell Death Immune Response-regulating Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Leukocyte Activation Positive Regulation Of Kinase Activity Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Growth Hormone Stimulus Mitotic Metaphase Plate Congression NAD Biosynthetic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Immune System Process Regulation Of Signaling Regulation Of Immune System Process Immune Response Cellular Response To Stimulus Regulation Of Immune Response Positive Regulation Of Signal Transduction Defense Response Cell Surface Receptor Signaling Pathway Response To Stimulus Fc-epsilon Receptor Signaling Pathway Signal Transduction Response To Wounding Peptidyl-tyrosine Phosphorylation Response To Organic Substance Cell Activation Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance ERBB Signaling Pathway Cell Differentiation Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Neurotrophin TRK Receptor Signaling Pathway Blood Coagulation Neurotrophin Signaling Pathway Hemostasis Antigen Receptor-mediated Signaling Pathway Locomotion System Development Cellular Response To Growth Factor Stimulus Response To Stress Peptidyl-tyrosine Autophosphorylation Regulation Of Body Fluid Levels Platelet Activation Response To Growth Factor Protein Autophosphorylation Developmental Process
Tagcloud ?		abundantly attractive bodies cascades constructed determines eb ebs embryoid escs fragments govern hesm01 hesm02 huge igf1r keep kinases libraries mak makes mark3 nek7 northern pluripotency raf semi undifferentiated unlimited	abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer
Tagcloud (Difference) ?		abundantly attractive bodies cascades constructed determines eb ebs embryoid escs fragments govern hesm01 hesm02 huge igf1r keep kinases libraries mak makes mark3 nek7 northern pluripotency raf semi undifferentiated unlimited	abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer
Tagcloud (Intersection) ?