NEK3 and PRLR

Number of citations: 0 (PubMedID 15618286)
Data Source: HPRD (in vivo)

		NEK3	PRLR
Name		NIMA related kinase 3	prolactin receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Axon Cell Projection	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endosome Lumen Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Protein Kinase Binding Cytokine Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Cell Division	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Response To Bacterium Cytokine-mediated Signaling Pathway Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Positive Regulation Of B Cell Proliferation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Mammary Gland Epithelium Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Cold-induced Thermogenesis
Pathways		None	Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs		Fostamatinib	Somatotropin Lonapegsomatropin
GWAS		No GWAS studies recorded	Advanced age-related macular degeneration ( 26691988 ) Appendicular lean mass ( 33097823 ) Chronotype ( 30696823 ) DHEAS levels ( 34748635 ) Metabolite levels ( 23823483 ) Paneth cell defects in Crohn's disease ( 28352666 ) Psychotic experience ( 31553412 ) Response to lurasidone in schizophrenia ( 29730043 )
Novel Interactors		None recorded	2 novel interactors: ICAM3 MFGE8
Interacting Genes		6 interacting genes: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2	20 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 INSIG2 JAK2 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		4752	5618
HPRD ID		04954	01457
Ensembl ID		ENSG00000136098	ENSG00000113494
Uniprot IDs		P51956 Q6ZN64	P16471
PDB IDs		Not available	1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
GO Terms Enriched among Interactors		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Phosphotyrosine Residue Binding Fc Receptor Signaling Pathway Cellular Response To Xenobiotic Stimulus Platelet Activation Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Size Phosphoglycerate Mutase Activity Nicotinamide Nucleotide Metabolic Process Bisphosphoglycerate Mutase Activity Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Receptor Activity Positive Regulation Of Signal Transduction Nicotinate-nucleotide Adenylyltransferase Activity Negative Regulation Of Apoptotic DNA Fragmentation Nicotinamide-nucleotide Adenylyltransferase Activity ATP Metabolic Process Prolactin Signaling Pathway Activation Of Janus Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein ADP-ribosyltransferase-substrate Adaptor Activity ATP Generation From Poly-ADP-D-ribose Nicotinamide Metabolic Process Chromosome Passenger Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Guanyl-nucleotide Exchange Factor Activity Purine Ribonucleotide Metabolic Process Intramolecular Phosphotransferase Activity Establishment Of Blood-brain Barrier Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Positive Regulation Of Immune System Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Mammary Gland Epithelium Development Prostate Gland Growth Response To Xenobiotic Stimulus Regulation Of Cellular Component Size Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Small GTPase-mediated Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphorylation-dependent Protein Binding Positive Regulation Of Mitotic Cytokinesis	Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Binding Protein Modification Process Regulation Of Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Endosome Lumen Growth Hormone Receptor Signaling Pathway Intracellular Signal Transduction Vesicle Positive Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Phosphorylation-dependent Protein Binding Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Prolactin Receptor Binding Positive Regulation Of Immune System Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Signal Transduction Cytokine Receptor Binding Developmental Process Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Sequestering Activity