NEK3 and VAV2

Number of citations of the paper that reports this interaction (PMID 15618286)
15

Data Source:
HPRD (in vivo, two hybrid)

		NEK3	VAV2
Gene Name		NIMA-related kinase 3	vav 2 guanine nucleotide exchange factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Axon	Cytosol Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Mitotic Nuclear Division Cell Division	Angiogenesis Signal Transduction Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Regulation Of Gene Expression Cell Migration Lamellipodium Assembly Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			Signaling by GPCR Axon guidance L1CAM interactions FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Rho GTPase cycle DAP12 signaling EPH-ephrin mediated repulsion of cells VEGFR2 mediated vascular permeability EPH-Ephrin signaling G alpha (12/13) signalling events Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Signalling by NGF DAP12 interactions Signal transduction by L1 Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling GPCR downstream signaling Signaling by VEGF NRAGE signals death through JNK Signaling by Rho GTPases GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Multiple sclerosis ( 20598377) vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		6 interactors: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2	62 interactors: ARIH1 BIRC6 BOD1L1 BRDT BZW1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 FNTA FUCA1 FYN GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MARCH7 MED21 MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1
Entrez ID		4752	7410
HPRD ID		04954	02694
Ensembl ID		ENSG00000136098	ENSG00000160293
Uniprot IDs		P51956 Q6ZN64	P52735
PDB IDs			2DLZ 2DM1 2LNW 2LNX
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Activation Of JAK2 Kinase Activity Immune System Process Prolactin Signaling Pathway Platelet Activation Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Rho GTPase Activity Phagocytosis Activation Of Janus Kinase Activity Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity T Cell Aggregation Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Prostate Gland Growth Lymphocyte Activation Fructose 2,6-bisphosphate Metabolic Process Blood Coagulation Positive Regulation Of Catalytic Activity Mammary Gland Epithelial Cell Differentiation Hemostasis Positive Regulation Of Ras GTPase Activity Regulation Of Cell Death Immune Response-regulating Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Leukocyte Activation Positive Regulation Of Kinase Activity Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Growth Hormone Stimulus Mitotic Metaphase Plate Congression NAD Biosynthetic Process	Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Response To Organic Substance Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Platelet Activation Innate Immune Response Regulation Of Cellular Protein Metabolic Process Cellular Protein Modification Process Cellular Metabolic Process Protein Metabolic Process Positive Regulation Of Viral Process Regulation Of Body Fluid Levels Wound Healing Immune Response Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Cell Activation Regulation Of Signal Transduction Response To Wounding Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Viral Process Positive Regulation Of Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Protein Ubiquitination Regulation Of Immune System Process Signal Transduction Regulation Of Intracellular Signal Transduction Chemotaxis Positive Regulation Of Homotypic Cell-cell Adhesion
Tagcloud ?		abundantly attractive bodies cascades constructed determines eb ebs embryoid escs fragments govern hesm01 hesm02 huge igf1r keep kinases libraries mak makes mark3 nek7 northern pluripotency raf semi undifferentiated unlimited	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		abundantly attractive bodies cascades constructed determines eb ebs embryoid escs fragments govern hesm01 hesm02 huge igf1r keep kinases libraries mak makes mark3 nek7 northern pluripotency raf semi undifferentiated unlimited	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?