NEK3 and NMNAT1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		NEK3	NMNAT1
Name		NIMA related kinase 3	nicotinamide nucleotide adenylyltransferase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Axon Cell Projection	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Nicotinamide-nucleotide Adenylyltransferase Activity Catalytic Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Identical Protein Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Cell Division	Purine Nucleotide Metabolic Process Nicotinamide Metabolic Process Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Response To Wounding Pyridine Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Adipose Tissue Development Positive Regulation Of Adipose Tissue Development ATP Generation From Poly-ADP-D-ribose
Pathways		None	Nicotinate metabolism
Drugs		Fostamatinib	Nicotinamide Mononucleotide Deamido-Nad+
GWAS		No GWAS studies recorded	Resting heart rate ( 27798624 )
Novel Interactors		None recorded	1 novel interactors: PABPC4
Interacting Genes		6 interacting genes: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2	19 interacting genes: APP BANP CCNC FLOT2 GORASP2 KPNA1 KPNA2 KPNA3 KPNA5 KPNA6 MSX1 NEK3 NFATC2IP NTRK2 PICK1 RNF4 SIK1 SIRT1 TDO2
Entrez ID		4752	64802
HPRD ID		04954	16369
Ensembl ID		ENSG00000136098	ENSG00000173614
Uniprot IDs		P51956 Q6ZN64	B1AN62 Q9HAN9
PDB IDs		Not available	1GZU 1KKU 1KQN 1KQO 1KR2 8QE8
GO Terms Enriched among Interactors		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Phosphotyrosine Residue Binding Fc Receptor Signaling Pathway Cellular Response To Xenobiotic Stimulus Platelet Activation Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Size Phosphoglycerate Mutase Activity Nicotinamide Nucleotide Metabolic Process Bisphosphoglycerate Mutase Activity Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Receptor Activity Positive Regulation Of Signal Transduction Nicotinate-nucleotide Adenylyltransferase Activity Negative Regulation Of Apoptotic DNA Fragmentation Nicotinamide-nucleotide Adenylyltransferase Activity ATP Metabolic Process Prolactin Signaling Pathway Activation Of Janus Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein ADP-ribosyltransferase-substrate Adaptor Activity ATP Generation From Poly-ADP-D-ribose Nicotinamide Metabolic Process Chromosome Passenger Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Guanyl-nucleotide Exchange Factor Activity Purine Ribonucleotide Metabolic Process Intramolecular Phosphotransferase Activity Establishment Of Blood-brain Barrier Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Positive Regulation Of Immune System Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Mammary Gland Epithelium Development Prostate Gland Growth Response To Xenobiotic Stimulus Regulation Of Cellular Component Size Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Small GTPase-mediated Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphorylation-dependent Protein Binding Positive Regulation Of Mitotic Cytokinesis	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Localization To Nucleus Intracellular Transport Of Virus Host Cell Protein Import Into Nucleus Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Triglyceride Biosynthetic Process Cellular Localization Intracellular Protein Transport Regulation Of Amyloid Precursor Protein Catabolic Process Intracellular Transport Establishment Of Protein Localization To Organelle Protein Localization To Organelle Negative Regulation Of Triglyceride Metabolic Process Establishment Of Localization In Cell Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Life Cycle Establishment Of Protein Localization Regulation Of Anoikis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Receptor Internalization Intracellular Protein Localization Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Cellular Response To Nerve Growth Factor Stimulus Protein Transport Viral Process Regulation Of Muscle Cell Differentiation