NEK3 and CDCA8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NEK3	CDCA8
Gene Name		NIMA-related kinase 3	cell division cycle associated 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Axon	Chromosome, Centromeric Region Nucleus Nucleolus Spindle Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein Complex Intercellular Bridge
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Phosphorylation Mitotic Nuclear Division Cell Division	Mitotic Cell Cycle Mitotic Metaphase Plate Congression Chromosome Organization Cell Division
Pathways			Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2	14 interactors: AURKB BIRC5 HIST2H3C HLA-DRB3 INCENP MAPKAPK5 NEK3 RANBP2 SGOL1 SGOL2 SUMO1 SUMO2 TTK UBE2I
Entrez ID		4752	55143
HPRD ID		04954	13017
Ensembl ID		ENSG00000136098	ENSG00000134690
Uniprot IDs		P51956 Q6ZN64	Q53HL2
PDB IDs			2KDD 2QFA 2RAW 2RAX
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Activation Of JAK2 Kinase Activity Immune System Process Prolactin Signaling Pathway Platelet Activation Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Rho GTPase Activity Phagocytosis Activation Of Janus Kinase Activity Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity T Cell Aggregation Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Prostate Gland Growth Lymphocyte Activation Fructose 2,6-bisphosphate Metabolic Process Blood Coagulation Positive Regulation Of Catalytic Activity Mammary Gland Epithelial Cell Differentiation Hemostasis Positive Regulation Of Ras GTPase Activity Regulation Of Cell Death Immune Response-regulating Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Leukocyte Activation Positive Regulation Of Kinase Activity Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Growth Hormone Stimulus Mitotic Metaphase Plate Congression NAD Biosynthetic Process	Chromosome Segregation Mitotic Cell Cycle Cell Cycle Process Protein Sumoylation Mitotic Cell Cycle Process Cell Division Cell Cycle Mitotic Nuclear Division Organelle Organization Spindle Checkpoint Mitotic Spindle Organization Peptidyl-amino Acid Modification Peptidyl-lysine Modification Cellular Protein Modification Process Attachment Of Spindle Microtubules To Kinetochore Protein Modification By Small Protein Conjugation Cytokinesis Spindle Organization Mitotic Spindle Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Microtubule Cytoskeleton Organization Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Division Regulation Of Proteolysis Microtubule Anchoring Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of SUMO Transferase Activity Protein Phosphorylation Negative Regulation Of Gene Expression Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule-based Process Meiotic Chromosome Segregation Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Spindle Assembly Protein Metabolic Process Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Protein Catabolic Process Negative Regulation Of Binding Histone H3-S28 Phosphorylation
Tagcloud ?		abundantly attractive bodies cascades constructed determines eb ebs embryoid escs fragments govern hesm01 hesm02 huge igf1r keep kinases libraries mak makes mark3 nek7 northern pluripotency raf semi undifferentiated unlimited	allele aurkb birc5 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		abundantly attractive bodies cascades constructed determines eb ebs embryoid escs fragments govern hesm01 hesm02 huge igf1r keep kinases libraries mak makes mark3 nek7 northern pluripotency raf semi undifferentiated unlimited	allele aurkb birc5 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?