TRIM56 and WEE2-AS1

Number of citations of the paper that reports this interaction (PubMedID 36168628)
47

Data Source:
BioGRID (unspecified method)

		TRIM56	WEE2-AS1
Description		tripartite motif containing 56	WEE2 antisense RNA 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	U1 SnRNP
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Pre-mRNA 5'-splice Site Binding
	Biological Process	Immune System Process Protein Monoubiquitination Protein Ubiquitination Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Response To Type I Interferon Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination CGAS/STING Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	MRNA 5'-splice Site Recognition
Pathways		Regulation of innate immune responses to cytosolic DNA
Drugs
Diseases
GWAS		Alzheimer's disease ( 30636644) Nonunion in individuals with fractures ( 30680360)
Interacting Genes		5 interacting genes: MIR200C MIR25 MIR34B UBE2H WEE2-AS1	161 interacting genes: AASS ACSL3 ACTG1 AGAP1 AHNAK AJUBA AKAP11 ALB ALKBH4 ANXA2 ARL6IP4 ASPSCR1 ATAD3A BCLAF1 BRAT1 CALML5 CLPB COPB2 COPG1 CSTF1 CTNND1 CTU2 DAXX DDX1 DDX23 DIDO1 DLST DNAAF5 DOHH DPYSL4 DSC1 DSP EEF1A1 EGR2 EIF3A ELL EMD EPM2AIP1 ERAP1 ERH EXOC4 FAM120B FAM83H FLG FLG2 FMR1 FOXK1 FXR1 FXR2 GAB1 GAPDH GBF1 GNL3 GRB10 GSDME GSN GTF3C1 GTPBP1 GTSE1 HARS1 HAX1 HMGA1 HMGCS1 HNRNPA2B1 HNRNPC HNRNPH1 HNRNPH2 HNRNPLL HNRNPM HSP90AA1 HSP90AB1 HSPA6 HSPA8 HSPB1 IFIT1 IGF2BP1 IGF2BP3 KCTD3 KIF20A KIF22 LAMC1 LARP7 LDLR LUC7L2 MAGED2 MAP1A MED23 MINDY3 MOB1A MSH6 MYH9 MYO1C NCKAP1 NDFIP1 NEK9 NISCH NPM1 NUP160 NXF1 PABPC1 PALS2 PARP1 PCMT1 PDCD2L PDXP PIGU PJA2 PLEC POP1 PPL PPM1F PRKAR2A PSMB1 PSMD1 PTK2 QTRT2 RAB5A RAF1 RETREG2 RPL13 RPLP2 RPN2 RPP30 RPRD1B RPS17 RPS2 RPS28 RPS29 RPS8 S100A14 S100A7 SEC13 SERBP1 SHKBP1 SHTN1 SKIC2 SLC25A11 SLC27A3 SNX8 SQSTM1 SRP68 STAT5B TANK THBS1 THRAP3 TIMELESS TMPO TOR1AIP2 TPR TRIM21 TRIM56 TRMT10C TTC28 TUBA1B TUBB3 TUBB4B U2AF1 UBB USP1 XRCC6 YBX1
Entrez ID		81844	285962
HPRD ID		10284	08286
Ensembl ID		ENSG00000169871	ENSG00000228775
Uniprot IDs		Q9BRZ2
PDB IDs		5JW7
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Muscle System Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Cardiac Muscle Hypertrophy RISC Complex MRNA Destabilization RNA Destabilization Regulation Of System Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Transmembrane Transport MRNA 3'-UTR Binding Negative Regulation Of Interleukin-33 Production Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Mesodermal Cell Differentiation Pre-mRNA 5'-splice Site Binding Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Calcium Ion Import Across Plasma Membrane MRNA 5'-splice Site Recognition Regulation Of Response To Drug Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endothelial Cell Differentiation Regulation Of Connective Tissue Replacement Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Multicellular Organismal Development U1 SnRNP Negative Regulation Of Transport Positive Regulation Of Tissue Remodeling Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Ubiquitin Conjugating Enzyme Activity MRNA Splice Site Recognition	RNA Binding Cytosol Ribonucleoprotein Complex Cytoplasm Nucleus Focal Adhesion Extracellular Exosome Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule MRNA Binding N6-methyladenosine-containing RNA Reader Activity Protein Binding MRNA Processing RNA Transport Nucleolus MRNA Transport Biological_process RNA Processing Nucleic Acid Binding Cellular Response To Heat Translation Regulator Activity Positive Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cornified Envelope Positive Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Heat Regulation Of Translation Regulation Of MRNA Stability CRD-mediated MRNA Stabilization Ficolin-1-rich Granule Lumen MRNA 3'-UTR Binding Nucleobase-containing Compound Transport Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Structural Molecule Activity Positive Regulation Of Gene Expression RNA Splicing Cadherin Binding Negative Regulation Of MRNA Catabolic Process Regulation Of Plasma Membrane Organization
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