TRIM56

Description		tripartite motif containing 56
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Protein Monoubiquitination Protein Ubiquitination Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Response To Type I Interferon Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination CGAS/STING Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Regulation of innate immune responses to cytosolic DNA
Drugs
Diseases
GWAS		Alzheimer's disease ( 30636644) Nonunion in individuals with fractures ( 30680360)
Interacting Genes		5 interacting genes: MIR200C MIR25 MIR34B UBE2H WEE2-AS1
Entrez ID		81844
HPRD ID		10284
Ensembl ID		ENSG00000169871
Uniprot IDs		Q9BRZ2
PDB IDs		5JW7
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Muscle System Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Cardiac Muscle Hypertrophy RISC Complex MRNA Destabilization RNA Destabilization Regulation Of System Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Transmembrane Transport MRNA 3'-UTR Binding Negative Regulation Of Interleukin-33 Production Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Mesodermal Cell Differentiation Pre-mRNA 5'-splice Site Binding Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Calcium Ion Import Across Plasma Membrane MRNA 5'-splice Site Recognition Regulation Of Response To Drug Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endothelial Cell Differentiation Regulation Of Connective Tissue Replacement Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Multicellular Organismal Development U1 SnRNP Negative Regulation Of Transport Positive Regulation Of Tissue Remodeling Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Ubiquitin Conjugating Enzyme Activity MRNA Splice Site Recognition
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