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RNF103 and UBE2L3
Number of citations of the paper that reports this interaction (PMID
18615712
)
1
Data Source:
BioGRID
(two hybrid)
RNF103
UBE2L3
Gene Name
ring finger protein 103
ubiquitin-conjugating enzyme E2L 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Poly(A) RNA Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activator Activity
Biological Process
Central Nervous System Development
Protein Ubiquitination
ER-associated Ubiquitin-dependent Protein Catabolic Process
Protein Polyubiquitination
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Cell Proliferation
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin-protein Transferase Activity
Protein K11-linked Ubiquitination
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Glucocorticoid Stimulus
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Celiac disease (
20190752
)
Celiac disease and Rheumatoid arthritis (
21383967
)
HDL cholesterol (
20686565
)
Inflammatory bowel disease (
23128233
)
Mean corpuscular volume (
20139978
)
Red blood cell traits (
23222517
)
Systemic lupus erythematosus (
23273568
21408207
19838193
)
Protein-Protein Interactions
11 interactors:
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2H
UBE2L3
UBE2N
UBE2W
UBE2Z
64 interactors:
ARIH1
ARIH2
ATXN3
BRCA1
CBL
CBLC
CCNB1IP1
CUL9
DTX3
FBXO2
FOS
HACE1
HERC3
HSPA4
HUWE1
ITCH
LIG4
MAPK6
MDM2
MID1
MKRN3
MUL1
NEDD4
NEDD4L
NFKBIA
NR3C1
PARK2
PJA1
POLR2A
PTEN
RAD23A
RBCK1
RBX1
RELA
RNF103
RNF113B
RNF125
RNF144A
RNF144B
RNF19A
RNF2
RNF216
SMAD4
SMAD7
SMURF1
SMURF2
STUB1
TRAF6
TRAF7
TRIM21
TRIM28
TRIM39
TRIP12
UBA1
UBA6
UBA7
UBASH3A
UBC
UBE3A
UBE3C
UBOX5
UBR5
WWP1
WWP2
Entrez ID
7844
7332
HPRD ID
03939
04762
Ensembl ID
ENSG00000239305
ENSG00000185651
Uniprot IDs
O00237
P68036
PDB IDs
1C4Z
1FBV
3SQV
3SY2
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Cellular Protein Modification Process
Cellular Macromolecule Catabolic Process
Cellular Protein Metabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Toll-like Receptor 4 Signaling Pathway
Proteolysis
Regulation Of Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Toll-like Receptor Signaling Pathway
Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Protein K63-linked Ubiquitination
Activation Of Innate Immune Response
Protein Monoubiquitination
Positive Regulation Of Innate Immune Response
Regulation Of Protein Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
TRIF-dependent Toll-like Receptor Signaling Pathway
ISG15-protein Conjugation
MyD88-independent Toll-like Receptor Signaling Pathway
Regulation Of Innate Immune Response
Toll-like Receptor 3 Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To Oxygen Levels
Cellular Response To Stress
Immune Response-regulating Signaling Pathway
Cellular Response To Organic Substance
Positive Regulation Of Transferase Activity
Cellular Metabolic Process
Regulation Of Chromosome Organization
Mitotic Spindle Assembly Checkpoint
Histone Ubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Modification Process
Cellular Macromolecule Catabolic Process
Cellular Protein Metabolic Process
Protein Polyubiquitination
Proteolysis
Protein Metabolic Process
Catabolic Process
Cellular Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Protein Ubiquitination
Viral Process
Regulation Of Protein Catabolic Process
Cellular Response To Organic Substance
Protein K63-linked Ubiquitination
Negative Regulation Of Signal Transduction
Protein K48-linked Ubiquitination
Negative Regulation Of Signaling
Protein Monoubiquitination
Cellular Response To Stress
Metabolic Process
Protein Autoubiquitination
Response To Stress
Regulation Of Signal Transduction
Intracellular Receptor Signaling Pathway
Cellular Response To Stimulus
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Organic Substance
Response To Growth Factor
Regulation Of Protein Metabolic Process
Regulation Of Type I Interferon Production
Regulation Of Signaling
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Cellular Metabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Cytokine Production
Response To Transforming Growth Factor Beta
Cellular Response To DNA Damage Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
DNA Repair
Positive Regulation Of Protein Catabolic Process
Tagcloud
?
2e37a
2e37b
cav
cav2
channel
channels
clathrin
conjugating
conserved
dynamin
inhibiting
interact
internalization
involves
lc1
light
map1b
mechanism
microtubule
prevented
propose
proteasome
proteolytic
q
triggered
ubiquitin
ubiquitination
variants
Tagcloud (Difference)
?
2e37a
2e37b
cav
cav2
channel
channels
clathrin
conjugating
conserved
dynamin
inhibiting
interact
internalization
involves
lc1
light
map1b
mechanism
microtubule
prevented
propose
proteasome
proteolytic
q
triggered
ubiquitin
ubiquitination
variants
Tagcloud (Intersection)
?