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RNF103 and UBE2D1
Number of citations of the paper that reports this interaction (PMID
19690564
)
33
Data Source:
BioGRID
(two hybrid)
RNF103
UBE2D1
Gene Name
ring finger protein 103
ubiquitin-conjugating enzyme E2D 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Ubiquitin Ligase Complex
Nucleoplasm
Cytoplasm
Cytosol
Protein Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Central Nervous System Development
Protein Ubiquitination
ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Protein Polyubiquitination
Mitotic Cell Cycle
Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Ubiquitin-dependent Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
BMP Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Protein K48-linked Ubiquitination
Cellular Response To Hypoxia
Pathways
Loss of Function of TGFBR2 in Cancer
Phosphorylation of the APC/C
Negative regulators of RIG-I/MDA5 signaling
Cellular Senescence
SMAD2/3 MH2 Domain Mutants in Cancer
APC/C:Cdc20 mediated degradation of Securin
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Signaling by BMP
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Generic Transcription Pathway
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TRIF-mediated TLR3/TLR4 signaling
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Loss of Function of SMAD4 in Cancer
Senescence-Associated Secretory Phenotype (SASP)
TGFBR1 KD Mutants in Cancer
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Cellular response to hypoxia
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Separation of Sister Chromatids
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
Mitotic Anaphase
TGFBR1 LBD Mutants in Cancer
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Activated TLR4 signalling
Class I MHC mediated antigen processing & presentation
Innate Immune System
Loss of Function of SMAD2/3 in Cancer
IKK complex recruitment mediated by RIP1
TGFBR2 Kinase Domain Mutants in Cancer
MyD88-independent cascade
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
Loss of Function of TGFBR1 in Cancer
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Regulation of mitotic cell cycle
Cell Cycle Checkpoints
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Brain imaging (
20100581
)
Crohn's disease (
21102463
)
Protein-Protein Interactions
11 interactors:
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2H
UBE2L3
UBE2N
UBE2W
UBE2Z
193 interactors:
AMFR
ANAPC11
ANXA1
ANXA7
AREL1
ARIH1
ARIH2
ASB2
ASB4
ASB9
BARD1
BFAR
BIRC2
BIRC3
BIRC6
BIRC7
BIRC8
BRCA1
BRCC3
BRE
BRMS1
C7orf25
CADPS2
CBL
CBLC
CDK7
CDKN1A
CHFR
CNOT4
CREBBP
CRYAB
CTNNB1
CUL2
CUL3
DDX58
DTL
DTX1
DTX2
DTX3
DTX3L
DZIP3
EP300
EPS15
F12
FAF2
FBXO2
FBXW7
FOS
FZR1
GADD45A
GSK3B
HDAC6
HERC3
HERC5
HIF1A
HSD17B10
HUWE1
KAT2B
KDM2B
KLHL13
KLHL2
KLHL9
LRSAM1
MAP3K1
MARCH1
MARCH2
MARCH4
MARCH5
MARCH7
MARCH8
MDM2
MDM4
MGRN1
MIB1
MID1
MID2
MKNK1
MKRN2
MKRN3
MUL1
MYLIP
NBN
NEDD4
NEDD4L
NEURL1
NFKBIA
NHLRC1
NR1H2
OTUB1
PELI1
PJA2
POLL
POLM
RABGEF1
RAD23A
RBX1
RELA
RFFL
RFWD2
RFWD3
RING1
RLIM
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF125
RNF126
RNF128
RNF13
RNF130
RNF14
RNF150
RNF165
RNF166
RNF167
RNF181
RNF182
RNF185
RNF2
RNF25
RNF26
RNF31
RNF38
RNF4
RNF43
RNF5
RNF6
RNF7
RNF8
SH3RF1
SIAH1
SIAH2
SIRT6
SIVA1
SKP1
SMURF2
STAM2
STUB1
TAF1D
TBL1X
TNFAIP3
TNNT1
TOM1
TOPORS
TP53
TRAF2
TRAF6
TRAF7
TRAIP
TRIM10
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM31
TRIM32
TRIM35
TRIM37
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM55
TRIM63
TRIM7
TRIM8
TRIP12
TSC22D1
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE3C
UBE4A
UBOX5
UFM1
UHRF2
VHL
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
7844
7321
HPRD ID
03939
04267
Ensembl ID
ENSG00000239305
ENSG00000072401
Uniprot IDs
O00237
P51668
PDB IDs
2C4P
2YHO
3OJ4
3PTF
4AP4
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Cellular Protein Modification Process
Cellular Macromolecule Catabolic Process
Cellular Protein Metabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Toll-like Receptor 4 Signaling Pathway
Proteolysis
Regulation Of Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Toll-like Receptor Signaling Pathway
Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Protein K63-linked Ubiquitination
Activation Of Innate Immune Response
Protein Monoubiquitination
Positive Regulation Of Innate Immune Response
Regulation Of Protein Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
TRIF-dependent Toll-like Receptor Signaling Pathway
ISG15-protein Conjugation
MyD88-independent Toll-like Receptor Signaling Pathway
Regulation Of Innate Immune Response
Toll-like Receptor 3 Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To Oxygen Levels
Cellular Response To Stress
Immune Response-regulating Signaling Pathway
Cellular Response To Organic Substance
Positive Regulation Of Transferase Activity
Cellular Metabolic Process
Regulation Of Chromosome Organization
Mitotic Spindle Assembly Checkpoint
Histone Ubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Metabolic Process
Cellular Macromolecule Catabolic Process
Protein Autoubiquitination
Proteolysis
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Protein Monoubiquitination
Cellular Response To Stress
Metabolic Process
Regulation Of Protein Metabolic Process
Response To Stress
Protein K48-linked Ubiquitination
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Proteasomal Protein Catabolic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Protein Ubiquitination
Negative Regulation Of Viral Release From Host Cell
Regulation Of Viral Release From Host Cell
Cellular Process
Protein K63-linked Ubiquitination
Regulation Of Signal Transduction
Regulation Of Metabolic Process
Cellular Response To Stimulus
Regulation Of Apoptotic Process
Innate Immune Response
Regulation Of Cell Death
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Response To Stimulus
Regulation Of Signaling
Tagcloud
?
accumulation
apoptosis
apoptotic
arsenic
cadmium
conjugating
degradation
downregulation
elevated
enzymes
family
hand
induce
inorganic
mercury
p53
promote
proteasomal
proximal
rat
suppressed
suppression
tubular
ubiquitin
ubiquitination
Tagcloud (Difference)
?
accumulation
apoptosis
apoptotic
arsenic
cadmium
conjugating
degradation
downregulation
elevated
enzymes
family
hand
induce
inorganic
mercury
p53
promote
proteasomal
proximal
rat
suppressed
suppression
tubular
ubiquitin
ubiquitination
Tagcloud (Intersection)
?