SCRIB and UBE3A

Number of citations of the paper that reports this interaction (PMID 11027293)
104

Data Source:
BioGRID (pull down)

		SCRIB	UBE3A
Gene Name		scribbled planar cell polarity protein	ubiquitin protein ligase E3A
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Basolateral Plasma Membrane Lamellipodium Cell Leading Edge Scrib-APC-beta-catenin Complex Myelin Sheath Abaxonal Region Presynaptic Membrane Postsynaptic Membrane Extracellular Vesicular Exosome	Proteasome Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity
	Biological Process	Neural Tube Closure Positive Regulation Of Receptor Recycling Asymmetric Protein Localization Cell Proliferation Viral Process Synaptic Vesicle Targeting Single Organismal Cell-cell Adhesion Cell Migration Cochlear Nucleus Development Activation Of Rac GTPase Activity Establishment Of Apical/basal Cell Polarity Wound Healing Positive Regulation Of Apoptotic Process Astrocyte Cell Migration Negative Regulation Of Mitotic Cell Cycle Synaptic Vesicle Endocytosis Positive Chemotaxis Auditory Receptor Cell Stereocilium Organization Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Sperm Entry Regulation Of Circadian Rhythm Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Asymmetric localization of PCP proteins Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661)
Protein-Protein Interactions		11 interactors: APC ARHGEF7 EXOSC10 LPP MAPK3 PRKCA STX4 TJP2 TRIP6 TSHR UBE3A	80 interactors: ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CDKN1B CEBPZ DLG1 EAPP EID1 EIF4G1 HBA1 HPCAL4 HSPA4 JADE1 KLHL38 LCK MAGEA8 MCM7 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PDE1B PGR PML POLE4 PRDX1 PSAP PSMC3 PSMD4 RAD23A RAD23B RARA RMI1 RNF2 SACS SCAMP1 SCRIB SGK223 SHBG SMAD9 SOD1 SUMO3 TAT TBC1D14 TCF19 TP53 TRIM65 TSC2 TTC3 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBQLN2 UCHL5 YOD1 YWHAE YWHAZ
Entrez ID		23513	7337
HPRD ID		06984	03375
Ensembl ID		ENSG00000180900	ENSG00000114062
Uniprot IDs		A0PJK8 Q14160	Q05086 Q9BUI6 Q9H2G0
PDB IDs		1UJU 1WHA 1X5Q 2W4F	1C4Z 1D5F 1EQX 2KR1 4GIZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell Junction Assembly Cell-cell Junction Organization Regulation Of Cell Migration Regulation Of Cell Motility Cell Activation Regulation Of Cellular Component Movement Positive Regulation Of Cell Adhesion Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Regulation Of Cellular Localization Cell Death Regulation Of Signal Transduction Death Signaling Platelet Activation Cell Communication Focal Adhesion Assembly Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Adherens Junction Assembly Cell-substrate Junction Assembly Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Sperm Entry Negative Regulation Of Apolipoprotein Binding Positive Regulation Of Dense Core Granule Biogenesis Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Execution Phase Of Apoptosis Neuron Development Response To Interleukin-1 Adherens Junction Organization Cell Development Blood Coagulation Hemostasis Intracellular Signal Transduction Positive Regulation Of Eosinophil Degranulation	Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Catabolic Process Response To Stress Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Checkpoint Cell Death Death Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Apoptotic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Regulation Of Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle Arrest Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Proteasomal Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Regulation Of Cell Cycle Catabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint
Tagcloud ?		asymmetry complex conserved crb crb3 crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles shape suppressor transport	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Difference) ?		asymmetry complex conserved crb crb3 crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles shape suppressor transport	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Intersection) ?