SCRIB and TJP2

Number of citations of the paper that reports this interaction (PMID 15975580)
19

Data Source:
HPRD (in vivo, in vitro)

		SCRIB	TJP2
Gene Name		scribbled planar cell polarity protein	tight junction protein 2
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Basolateral Plasma Membrane Lamellipodium Cell Leading Edge Scrib-APC-beta-catenin Complex Myelin Sheath Abaxonal Region Presynaptic Membrane Postsynaptic Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Tight Junction Cell Junction
	Molecular Function	Protein Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging
	Biological Process	Neural Tube Closure Positive Regulation Of Receptor Recycling Asymmetric Protein Localization Cell Proliferation Viral Process Synaptic Vesicle Targeting Single Organismal Cell-cell Adhesion Cell Migration Cochlear Nucleus Development Activation Of Rac GTPase Activity Establishment Of Apical/basal Cell Polarity Wound Healing Positive Regulation Of Apoptotic Process Astrocyte Cell Migration Negative Regulation Of Mitotic Cell Cycle Synaptic Vesicle Endocytosis Positive Chemotaxis Auditory Receptor Cell Stereocilium Organization Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Organic Substance Hippo Signaling Nucleotide Phosphorylation Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability
Pathways		Asymmetric localization of PCP proteins Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Signaling by Hippo Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS			Refractive error ( 23396134) Renal sinus fat ( 22044751)
Protein-Protein Interactions		11 interactors: APC ARHGEF7 EXOSC10 LPP MAPK3 PRKCA STX4 TJP2 TRIP6 TSHR UBE3A	15 interactors: CDK6 CGN CLDN1 CLDN2 CTNNA1 EPB41 HGS OCLN SAFB SCRIB SH3KBP1 TJP1 YWHAB YWHAG YWHAZ
Entrez ID		23513	9414
HPRD ID		06984	06369
Ensembl ID		ENSG00000180900	ENSG00000119139
Uniprot IDs		A0PJK8 Q14160	B7Z2R3 B7Z954 Q9UDY2
PDB IDs		1UJU 1WHA 1X5Q 2W4F	2OSG 3E17
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell Junction Assembly Cell-cell Junction Organization Regulation Of Cell Migration Regulation Of Cell Motility Cell Activation Regulation Of Cellular Component Movement Positive Regulation Of Cell Adhesion Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Regulation Of Cellular Localization Cell Death Regulation Of Signal Transduction Death Signaling Platelet Activation Cell Communication Focal Adhesion Assembly Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Adherens Junction Assembly Cell-substrate Junction Assembly Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Sperm Entry Negative Regulation Of Apolipoprotein Binding Positive Regulation Of Dense Core Granule Biogenesis Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Execution Phase Of Apoptosis Neuron Development Response To Interleukin-1 Adherens Junction Organization Cell Development Blood Coagulation Hemostasis Intracellular Signal Transduction Positive Regulation Of Eosinophil Degranulation	Cell-cell Junction Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cell-cell Junction Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Death Cell Junction Assembly Positive Regulation Of Apoptotic Signaling Pathway Apical Junction Assembly Positive Regulation Of Mitochondrion Organization Epithelial Cell Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Mitochondrion Organization Signaling Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell Communication Protein Targeting Membrane Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Hippo Signaling Enzyme Linked Receptor Protein Signaling Pathway Intrinsic Apoptotic Signaling Pathway Signal Transduction Epithelial Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tight Junction Assembly Positive Regulation Of Intracellular Transport Negative Regulation Of ERBB Signaling Pathway Cell Development Cell Adhesion Cellular Component Assembly Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Involved In Cell-cell Junction Organization Cell Dedifferentiation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Signal Transduction Positive Regulation Of Transport Cellular Protein Localization Execution Phase Of Apoptosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Apoptotic Signaling Pathway Negative Regulation Of Integrin-mediated Signaling Pathway
Tagcloud ?		asymmetry complex conserved crb crb3 crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles shape suppressor transport
Tagcloud (Difference) ?		asymmetry complex conserved crb crb3 crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles shape suppressor transport
Tagcloud (Intersection) ?