SCRIB and LPP

Number of citations of the paper that reports this interaction (PMID 16137684)
8

Data Source:
HPRD (in vivo)

		SCRIB	LPP
Gene Name		scribbled planar cell polarity protein	LIM domain containing preferred translocation partner in lipoma
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Basolateral Plasma Membrane Lamellipodium Cell Leading Edge Scrib-APC-beta-catenin Complex Myelin Sheath Abaxonal Region Presynaptic Membrane Postsynaptic Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Focal Adhesion
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding
	Biological Process	Neural Tube Closure Positive Regulation Of Receptor Recycling Asymmetric Protein Localization Cell Proliferation Viral Process Synaptic Vesicle Targeting Single Organismal Cell-cell Adhesion Cell Migration Cochlear Nucleus Development Activation Of Rac GTPase Activity Establishment Of Apical/basal Cell Polarity Wound Healing Positive Regulation Of Apoptotic Process Astrocyte Cell Migration Negative Regulation Of Mitotic Cell Cycle Synaptic Vesicle Endocytosis Positive Chemotaxis Auditory Receptor Cell Stereocilium Organization Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction	Cell Adhesion Biological_process
Pathways		Asymmetric localization of PCP proteins Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			B cell non-Hodgkin lymphoma ( 23749188) Celiac disease ( 20190752 18311140) IgE levels ( 22075330) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Obesity-related traits ( 23251661) Renal function-related traits (BUN) ( 22797727) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 22951725 20410501) White matter integrity (interaction) ( 23218918)
Protein-Protein Interactions		11 interactors: APC ARHGEF7 EXOSC10 LPP MAPK3 PRKCA STX4 TJP2 TRIP6 TSHR UBE3A	6 interactors: ACTN1 ATP5J2 ATRAID SCRIB SHPRH VASP
Entrez ID		23513	4026
HPRD ID		06984	02828
Ensembl ID		ENSG00000180900	ENSG00000145012
Uniprot IDs		A0PJK8 Q14160	B7Z8W0 B7ZLW0 Q93052
PDB IDs		1UJU 1WHA 1X5Q 2W4F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell Junction Assembly Cell-cell Junction Organization Regulation Of Cell Migration Regulation Of Cell Motility Cell Activation Regulation Of Cellular Component Movement Positive Regulation Of Cell Adhesion Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Regulation Of Cellular Localization Cell Death Regulation Of Signal Transduction Death Signaling Platelet Activation Cell Communication Focal Adhesion Assembly Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Adherens Junction Assembly Cell-substrate Junction Assembly Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Sperm Entry Negative Regulation Of Apolipoprotein Binding Positive Regulation Of Dense Core Granule Biogenesis Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Execution Phase Of Apoptosis Neuron Development Response To Interleukin-1 Adherens Junction Organization Cell Development Blood Coagulation Hemostasis Intracellular Signal Transduction Positive Regulation Of Eosinophil Degranulation	Protein Localization To Cell Junction Neural Tube Closure Neural Tube Formation Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Cyclin Catabolic Process Tube Formation Morphogenesis Of Embryonic Epithelium Protein Localization To Tight Junction Cochlear Nucleus Development Protein Localization To Adherens Junction Neural Tube Development Cell Junction Assembly Establishment Of Apical/basal Cell Polarity Synaptic Vesicle Targeting Astrocyte Cell Migration Actin Filament Organization Auditory Receptor Cell Stereocilium Organization Establishment Of Monopolar Cell Polarity Exocytosis Pons Development Negative Regulation Of Osteoblast Proliferation Auditory Receptor Cell Morphogenesis Activation Of Rac GTPase Activity Epithelial Tube Morphogenesis Mitochondrial ATP Synthesis Coupled Proton Transport Auditory Receptor Cell Development Actin Crosslink Formation Positive Regulation Of Receptor Recycling Tube Morphogenesis Inner Ear Receptor Stereocilium Organization
Tagcloud ?		asymmetry complex conserved crb crb3 crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles shape suppressor transport	arousal behavioural correlation degree denenberg describes direction documented exhibit lateral lateralities medial mpp paw periods preference preferences regardless relations rodents seemingly side sp spatial states strength strong terms waters
Tagcloud (Difference) ?		asymmetry complex conserved crb crb3 crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles shape suppressor transport	arousal behavioural correlation degree denenberg describes direction documented exhibit lateral lateralities medial mpp paw periods preference preferences regardless relations rodents seemingly side sp spatial states strength strong terms waters
Tagcloud (Intersection) ?