SCRIB and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SCRIB	C5AR2
Description		scribble planar cell polarity protein	complement C5a receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Postsynaptic Density Membrane Basolateral Plasma Membrane Lamellipodium Cell Junction Cell Leading Edge Scrib-APC-beta-catenin Complex Myelin Sheath Abaxonal Region Presynaptic Membrane Cell Projection Cell-cell Contact Zone Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction Presynapse Postsynapse Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Plasma Membrane Basal Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Adaptor Activity Cadherin Binding	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Establishment Of T Cell Polarity Neural Tube Closure Positive Regulation Of Receptor Recycling Auditory Receptor Cell Morphogenesis Regulation Of Translation Intracellular Protein Localization Cell Population Proliferation Epithelial Structure Maintenance Positive Regulation Of Epithelial To Mesenchymal Transition Synaptic Vesicle Targeting Morphogenesis Of Embryonic Epithelium Cell Migration Cochlear Nucleus Development Establishment Of Cell Polarity Cell Differentiation Polarized Epithelial Cell Differentiation Positive Regulation Of Type II Interferon Production Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Apical/basal Cell Polarity Post-anal Tail Morphogenesis Wound Healing Positive Regulation Of Apoptotic Process Receptor Clustering Astrocyte Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Negative Regulation Of Activated T Cell Proliferation Synaptic Vesicle Endocytosis Positive Chemotaxis Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Stereocilium Organization Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction Activation Of GTPase Activity Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Chemotaxis
Pathways		Asymmetric localization of PCP proteins CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RND3 GTPase cycle RND2 GTPase cycle	Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)
Interacting Genes		18 interacting genes: ACE2 ACVR2B APC ARHGEF7 BRSK2 C5AR2 DYRK1A EXOSC10 LPP MAPK3 OGT PRKCA STX4 TJP2 TRIP6 TSHR UBE3A VANGL2	17 interacting genes: ABCA7 ACO2 ARLN C3 C4A C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		23513	27202
HPRD ID		06984	17072
Ensembl ID		ENSG00000180900	ENSG00000134830
Uniprot IDs		A0A0G2JNZ2 A0A0G2JPP5 A0PJK8 Q14160	Q9P296
PDB IDs		1UJU 1WHA 1X5Q 2W4F 4WYT 4WYU 5VWC 5VWI 5VWK 6EEY 6ESP 6MS1 6MTU 6MTV 6MYE 6MYF 6XA6 6XA7 6XA8 7JO7 7QRS 7QRT 7QS8 7QS9 7QSA 7QSB 7QTO 7QTP 7QTU 8B82 8B87 8B8O 8B9T 8BIA 8BJ0 8CD3
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Motility Regulation Of Cell Migration Anchoring Junction Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Cold-induced Thermogenesis Regulation Of Signaling Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Plasma Membrane Regulation Of Biological Quality Cell Junction Organization Negative Regulation Of Microtubule Polymerization Stress Fiber Protein Kinase Activity Cell Junction Assembly Regulation Of TORC1 Signaling Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Cold-induced Thermogenesis Regulation Of Hormone Levels Regulation Of Cytoskeleton Organization Signal Transduction Intracellular Signal Transduction Regulation Of Protein Localization Tau-protein Kinase Activity Glutamatergic Synapse Kinase Activity Negative Regulation Of Protein-containing Complex Assembly Focal Adhesion Assembly Protein Serine/threonine/tyrosine Kinase Activity Protein Phosphorylation Response To Stress Protein Serine Kinase Activity System Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytoskeleton Organization Regulation Of TOR Signaling Negative Regulation Of Supramolecular Fiber Organization Phosphorylation Negative Regulation Of Cellular Component Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Insulin Secretion Negative Regulation Of Metabolic Process Cell-cell Junction Organization Positive Regulation Of Metabolic Process	Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Classical-complement-pathway C3/C5 Convertase Complex Amyloid-beta Clearance Regulation Of Endocytosis Positive Regulation Of Phagocytosis Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Opsonization Regulation Of Phagocytosis Regulation Of Vesicle-mediated Transport Symbiont Cell Surface Transmembrane Transporter Binding Locomotion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endocytosis Antigen Binding Complement Activation, Classical Pathway Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Endopeptidase Inhibitor Activity Plasma Membrane Presynaptic Endocytosis Corticospinal Neuron Axon Guidance Oxoglutarate:malate Antiporter Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Complement Activation Positive Regulation Of Activation Of Membrane Attack Complex Basolateral Plasma Membrane Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Positive Regulation Of Voltage-gated Sodium Channel Activity Apolipoprotein A-I Receptor Activity Positive Regulation Of Engulfment Of Apoptotic Cell Regulation Of Engulfment Of Apoptotic Cell Scrib-APC-beta-catenin Complex
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