SCRIB and TSHR

Number of citations of the paper that reports this interaction (PubMedID 15775968)
50

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SCRIB	TSHR
Description		scribble planar cell polarity protein	thyroid stimulating hormone receptor
Image
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Postsynaptic Density Membrane Basolateral Plasma Membrane Lamellipodium Cell Junction Cell Leading Edge Scrib-APC-beta-catenin Complex Myelin Sheath Abaxonal Region Presynaptic Membrane Cell Projection Cell-cell Contact Zone Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction Presynapse Postsynapse Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Adaptor Activity Cadherin Binding	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding
	Biological Process	Establishment Of T Cell Polarity Neural Tube Closure Positive Regulation Of Receptor Recycling Auditory Receptor Cell Morphogenesis Regulation Of Translation Intracellular Protein Localization Cell Population Proliferation Epithelial Structure Maintenance Positive Regulation Of Epithelial To Mesenchymal Transition Synaptic Vesicle Targeting Morphogenesis Of Embryonic Epithelium Cell Migration Cochlear Nucleus Development Establishment Of Cell Polarity Cell Differentiation Polarized Epithelial Cell Differentiation Positive Regulation Of Type II Interferon Production Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Apical/basal Cell Polarity Post-anal Tail Morphogenesis Wound Healing Positive Regulation Of Apoptotic Process Receptor Clustering Astrocyte Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Negative Regulation Of Activated T Cell Proliferation Synaptic Vesicle Endocytosis Positive Chemotaxis Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Stereocilium Organization Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction Activation Of GTPase Activity Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone
Pathways		Asymmetric localization of PCP proteins CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RND3 GTPase cycle RND2 GTPase cycle	Hormone ligand-binding receptors G alpha (s) signalling events
Drugs			Thyrotropin alfa
Diseases			Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Menarche (age at onset) ( 25231870)	Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)
Interacting Genes		18 interacting genes: ACE2 ACVR2B APC ARHGEF7 BRSK2 C5AR2 DYRK1A EXOSC10 LPP MAPK3 OGT PRKCA STX4 TJP2 TRIP6 TSHR UBE3A VANGL2	38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB
Entrez ID		23513	7253
HPRD ID		06984	04537
Ensembl ID		ENSG00000180900	ENSG00000165409
Uniprot IDs		A0A0G2JNZ2 A0A0G2JPP5 A0PJK8 Q14160	P16473
PDB IDs		1UJU 1WHA 1X5Q 2W4F 4WYT 4WYU 5VWC 5VWI 5VWK 6EEY 6ESP 6MS1 6MTU 6MTV 6MYE 6MYF 6XA6 6XA7 6XA8 7JO7 7QRS 7QRT 7QS8 7QS9 7QSA 7QSB 7QTO 7QTP 7QTU 8B82 8B87 8B8O 8B9T 8BIA 8BJ0 8CD3	2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Motility Regulation Of Cell Migration Anchoring Junction Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Cold-induced Thermogenesis Regulation Of Signaling Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Plasma Membrane Regulation Of Biological Quality Cell Junction Organization Negative Regulation Of Microtubule Polymerization Stress Fiber Protein Kinase Activity Cell Junction Assembly Regulation Of TORC1 Signaling Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Cold-induced Thermogenesis Regulation Of Hormone Levels Regulation Of Cytoskeleton Organization Signal Transduction Intracellular Signal Transduction Regulation Of Protein Localization Tau-protein Kinase Activity Glutamatergic Synapse Kinase Activity Negative Regulation Of Protein-containing Complex Assembly Focal Adhesion Assembly Protein Serine/threonine/tyrosine Kinase Activity Protein Phosphorylation Response To Stress Protein Serine Kinase Activity System Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytoskeleton Organization Regulation Of TOR Signaling Negative Regulation Of Supramolecular Fiber Organization Phosphorylation Negative Regulation Of Cellular Component Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Insulin Secretion Negative Regulation Of Metabolic Process Cell-cell Junction Organization Positive Regulation Of Metabolic Process	G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure
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