SCRIB and ARHGEF7

Number of citations of the paper that reports this interaction (PubMedID 15182672)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SCRIB	ARHGEF7
Description		scribble planar cell polarity protein	Rho guanine nucleotide exchange factor 7
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GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Postsynaptic Density Membrane Basolateral Plasma Membrane Lamellipodium Cell Junction Cell Leading Edge Scrib-APC-beta-catenin Complex Myelin Sheath Abaxonal Region Presynaptic Membrane Cell Projection Cell-cell Contact Zone Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction Presynapse Postsynapse Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Ruffle Cytoplasm Centrosome Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Cell Projection Neuron Projection Neuronal Cell Body Anchoring Junction Mitotic Spindle Pole Postsynapse
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Adaptor Activity Cadherin Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Gamma-tubulin Binding
	Biological Process	Establishment Of T Cell Polarity Neural Tube Closure Positive Regulation Of Receptor Recycling Auditory Receptor Cell Morphogenesis Regulation Of Translation Intracellular Protein Localization Cell Population Proliferation Epithelial Structure Maintenance Positive Regulation Of Epithelial To Mesenchymal Transition Synaptic Vesicle Targeting Morphogenesis Of Embryonic Epithelium Cell Migration Cochlear Nucleus Development Establishment Of Cell Polarity Cell Differentiation Polarized Epithelial Cell Differentiation Positive Regulation Of Type II Interferon Production Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Apical/basal Cell Polarity Post-anal Tail Morphogenesis Wound Healing Positive Regulation Of Apoptotic Process Receptor Clustering Astrocyte Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Negative Regulation Of Activated T Cell Proliferation Synaptic Vesicle Endocytosis Positive Chemotaxis Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Stereocilium Organization Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction Activation Of GTPase Activity Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Golgi Organization Signal Transduction Rho Protein Signal Transduction Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Microtubule Nucleation Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Asymmetric localization of PCP proteins CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RND3 GTPase cycle RND2 GTPase cycle	EGFR downregulation NRAGE signals death through JNK Ephrin signaling G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824) Weight ( 34074324)
Interacting Genes		18 interacting genes: ACE2 ACVR2B APC ARHGEF7 BRSK2 C5AR2 DYRK1A EXOSC10 LPP MAPK3 OGT PRKCA STX4 TJP2 TRIP6 TSHR UBE3A VANGL2	37 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN FXR1 FXR2 GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PRRG4 PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 VHL WAS YWHAG
Entrez ID		23513	8874
HPRD ID		06984	05688
Ensembl ID		ENSG00000180900	ENSG00000102606
Uniprot IDs		A0A0G2JNZ2 A0A0G2JPP5 A0PJK8 Q14160	A0A2R8YG42 A0A8V8TQ72 B1ALK7 B7Z344 B7Z6G2 E9PDQ5 Q14155
PDB IDs		1UJU 1WHA 1X5Q 2W4F 4WYT 4WYU 5VWC 5VWI 5VWK 6EEY 6ESP 6MS1 6MTU 6MTV 6MYE 6MYF 6XA6 6XA7 6XA8 7JO7 7QRS 7QRT 7QS8 7QS9 7QSA 7QSB 7QTO 7QTP 7QTU 8B82 8B87 8B8O 8B9T 8BIA 8BJ0 8CD3	1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Motility Regulation Of Cell Migration Anchoring Junction Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Cold-induced Thermogenesis Regulation Of Signaling Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Plasma Membrane Regulation Of Biological Quality Cell Junction Organization Negative Regulation Of Microtubule Polymerization Stress Fiber Protein Kinase Activity Cell Junction Assembly Regulation Of TORC1 Signaling Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Cold-induced Thermogenesis Regulation Of Hormone Levels Regulation Of Cytoskeleton Organization Signal Transduction Intracellular Signal Transduction Regulation Of Protein Localization Tau-protein Kinase Activity Glutamatergic Synapse Kinase Activity Negative Regulation Of Protein-containing Complex Assembly Focal Adhesion Assembly Protein Serine/threonine/tyrosine Kinase Activity Protein Phosphorylation Response To Stress Protein Serine Kinase Activity System Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytoskeleton Organization Regulation Of TOR Signaling Negative Regulation Of Supramolecular Fiber Organization Phosphorylation Negative Regulation Of Cellular Component Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Insulin Secretion Negative Regulation Of Metabolic Process Cell-cell Junction Organization Positive Regulation Of Metabolic Process	Regulation Of Signaling Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Stress Fiber Assembly Postsynapse Regulation Of Cell Communication Regulation Of Actin Cytoskeleton Organization Regulation Of Signal Transduction Regulation Of Actin Filament-based Process Cell-cell Junction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Signal Transduction Glutamatergic Synapse Positive Regulation Of Stress Fiber Assembly Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cytoskeleton Organization Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Plasma Membrane Modulation Of Chemical Synaptic Transmission Enzyme-linked Receptor Protein Signaling Pathway Cell Projection Small GTPase Binding SH3 Domain Binding Lamellipodium Regulation Of Synaptic Plasticity Cytosol Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Dendrite Neuron Projection Regulation Of Organelle Organization Cytoplasm Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Organelle Organization Protein Localization To Cell Junction Postsynaptic Density Positive Regulation Of T Cell Tolerance Induction Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Regulation Of Locomotion
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