SCRIB and ARHGEF7

Number of citations of the paper that reports this interaction (PMID 15182672)
54

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		SCRIB	ARHGEF7
Gene Name		scribbled planar cell polarity protein	Rho guanine nucleotide exchange factor (GEF) 7
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Basolateral Plasma Membrane Lamellipodium Cell Leading Edge Scrib-APC-beta-catenin Complex Myelin Sheath Abaxonal Region Presynaptic Membrane Postsynaptic Membrane Extracellular Vesicular Exosome	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Neuron Projection Neuronal Cell Body Protein Complex
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Neural Tube Closure Positive Regulation Of Receptor Recycling Asymmetric Protein Localization Cell Proliferation Viral Process Synaptic Vesicle Targeting Single Organismal Cell-cell Adhesion Cell Migration Cochlear Nucleus Development Activation Of Rac GTPase Activity Establishment Of Apical/basal Cell Polarity Wound Healing Positive Regulation Of Apoptotic Process Astrocyte Cell Migration Negative Regulation Of Mitotic Cell Cycle Synaptic Vesicle Endocytosis Positive Chemotaxis Auditory Receptor Cell Stereocilium Organization Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction	Hematopoietic Progenitor Cell Differentiation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Positive Regulation Of Rac GTPase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Asymmetric localization of PCP proteins Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	EGFR downregulation Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Rho GTPase cycle Signaling by EGFR GPCR downstream signaling Ephrin signaling NRAGE signals death through JNK Signaling by Rho GTPases Signaling by EGFR in Cancer EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS			Bilirubin levels ( 19414484) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619)
Protein-Protein Interactions		11 interactors: APC ARHGEF7 EXOSC10 LPP MAPK3 PRKCA STX4 TJP2 TRIP6 TSHR UBE3A	28 interactors: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 ERBB2IP GIT1 GIT2 LRRK2 MEOX2 NCK1 NCKIPSD PAK1 PAK2 PAK3 PPM1E PPM1F PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG
Entrez ID		23513	8874
HPRD ID		06984	05688
Ensembl ID		ENSG00000180900	ENSG00000102606
Uniprot IDs		A0PJK8 Q14160	B7Z6G2 E9PDQ5 Q14155
PDB IDs		1UJU 1WHA 1X5Q 2W4F	1BY1 1ZSG 2L3G
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell Junction Assembly Cell-cell Junction Organization Regulation Of Cell Migration Regulation Of Cell Motility Cell Activation Regulation Of Cellular Component Movement Positive Regulation Of Cell Adhesion Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Regulation Of Cellular Localization Cell Death Regulation Of Signal Transduction Death Signaling Platelet Activation Cell Communication Focal Adhesion Assembly Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Adherens Junction Assembly Cell-substrate Junction Assembly Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Sperm Entry Negative Regulation Of Apolipoprotein Binding Positive Regulation Of Dense Core Granule Biogenesis Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Execution Phase Of Apoptosis Neuron Development Response To Interleukin-1 Adherens Junction Organization Cell Development Blood Coagulation Hemostasis Intracellular Signal Transduction Positive Regulation Of Eosinophil Degranulation	Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity Regulation Of Signaling Cell Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cell Adhesion Regulation Of T Cell Activation Neuron Projection Morphogenesis Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Positive Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Development Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Positive Regulation Of T Cell Activation Neuron Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Actin Cytoskeleton Organization Nervous System Development Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Positive Regulation Of Transferase Activity Axon Guidance Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Development
Tagcloud ?		asymmetry complex conserved crb crb3 crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles shape suppressor transport
Tagcloud (Difference) ?		asymmetry complex conserved crb crb3 crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles shape suppressor transport
Tagcloud (Intersection) ?