TRPC3 and VAMP2

Number of citations of the paper that reports this interaction (PMID 15327778)
42

Data Source:
HPRD (in vivo, two hybrid)

		TRPC3	VAMP2
Gene Name		transient receptor potential cation channel, subfamily C, member 3	vesicle-associated membrane protein 2 (synaptobrevin 2)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Membrane Cell Junction Clathrin-coated Vesicle Secretory Granule Secretory Granule Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Zymogen Granule Membrane Neuron Projection Intracellular Membrane-bounded Organelle Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Vesicular Exosome Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Protein Self-association Calcium-dependent Protein Binding
	Biological Process	Calcium Ion Transport Axon Guidance Blood Coagulation Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Energy Reserve Metabolic Process Protein Complex Assembly Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Glucose Glutamate Secretion Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium Ion-dependent Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Organization Membrane Fusion Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Histamine Secretion By Mast Cell
Pathways		G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type D (BoNT/D) Golgi Associated Vesicle Biogenesis Translocation of GLUT4 to the plasma membrane GABA synthesis, release, reuptake and degradation Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins trans-Golgi Network Vesicle Budding Toxicity of botulinum toxin type G (BoNT/G) Regulation of insulin secretion Norepinephrine Neurotransmitter Release Cycle Toxicity of tetanus toxin (TeNT) Toxicity of botulinum toxin type F (BoNT/F) Glutamate Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Insulin processing Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2	26 interactors: ASNA1 ATP13A2 BAG6 BCAP31 CPLX1 FKBP2 PRKD3 RABAC1 SNAP23 SNAP25 SNAP29 STX11 STX1A STX1B STX2 STX3 STX4 STXBP2 STXBP3 SYP SYPL1 TRPC3 VAMP3 VAMP8 VAPA VAPB
Entrez ID		7222	6844
HPRD ID		15999	01717
Ensembl ID		ENSG00000138741	ENSG00000220205
Uniprot IDs		J3QTB0 Q13507	F8WCA0 P63027
PDB IDs			3FIE 3FII 3RK2 3RK3 3RL0
Enriched GO Terms of Interacting Partners?		Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Activation Of Phospholipase C Activity Calcium Ion Transmembrane Transport Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Cell Activation Regulation Of Phospholipase Activity Calcium Ion Transport Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Platelet Activation Inositol Phosphate Metabolic Process Second-messenger-mediated Signaling Cellular Calcium Ion Homeostasis Regulation Of Ion Homeostasis Calcium Ion Homeostasis Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Synaptic Transmission Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Metal Ion Homeostasis Energy Reserve Metabolic Process Cellular Chemical Homeostasis Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Metal Ion Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Ion Homeostasis Chemical Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Signaling Response To Stimulus Cation Transmembrane Transport Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ion Transport Response To Fibroblast Growth Factor Regulation Of Calcium Ion Transport Into Cytosol	Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Fusion Vesicle Organization Organelle Fusion Membrane Fusion Synaptic Vesicle Exocytosis Exocytosis Neurotransmitter Secretion Synaptic Vesicle Transport Vesicle Docking Membrane Organization Membrane Docking Regulation Of Neurotransmitter Levels Neurotransmitter Transport Secretion By Cell Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization Secretion Cellular Localization Establishment Of Organelle Localization Establishment Of Localization In Cell Cell-cell Signaling Transport Establishment Of Protein Localization Protein Localization Organelle Localization Synaptic Transmission Protein Transport Vesicle Docking Involved In Exocytosis Regulation Of Exocytosis Cell Communication Regulation Of Cellular Localization Signaling Organelle Organization Golgi Vesicle Transport Regulation Of Secretion Intracellular Transport Neutrophil Degranulation Cellular Protein Localization Synaptic Vesicle Docking SNARE Complex Assembly Regulation Of Vesicle-mediated Transport Neutrophil Activation Involved In Immune Response Synaptic Vesicle Priming Positive Regulation Of Synaptic Transmission Leukocyte Degranulation Regulated Secretory Pathway Regulation Of Synaptic Transmission Negative Regulation By Host Of Viral Genome Replication
Tagcloud ?		channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1	adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp1
Tagcloud (Difference) ?		channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1	adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp1
Tagcloud (Intersection) ?