VAMP2

Name	vesicle associated membrane protein 2
Structure
Interactors	47 interactors: AQP6 ARL13B ATP13A2 BAG6 BCAP31 CERS4 CPLX1 CREB3L1 EBP ERGIC3 EXOC3 FKBP2 GET3 HIBADH HSD17B13 JAGN1 KASH5 LMNA MARCHF8 PRKD3 RABAC1 SCN3B SLC30A8 SLC6A4 SLC7A14 SNAP23 SNAP25 SNCA STX11 STX1A STX1B STX2 STX4 STXBP2 STXBP3 SYP SYPL1 TMEM101 TMEM31 TMEM86B TRPC3 VAMP3 VAMP8 VAPA VAPB VCP VMA21
GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Vesicle Zymogen Granule Membrane Neuron Projection Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding
	Biological Process	Exocytosis Vesicle Fusion Response To Glucose Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Synaptic Vesicle Endocytosis Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Histamine Secretion By Mast Cell
Pathways	Translocation of SLC2A4 (GLUT4) to the plasma membrane Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle trans-Golgi Network Vesicle Budding Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Other interleukin signaling Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type F (botF) Toxicity of tetanus toxin (tetX) Toxicity of botulinum toxin type G (botG) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea
Drugs	Botulinum toxin type B
GWAS	Chronotype ( 30696823 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Morning person ( 30696823 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )
Entrez ID	6844
HPRD ID	01717
Ensembl ID	ENSG00000220205
Uniprot IDs	F8WCA0 P63027
PDB IDs	3FIE 3FII 3RK2 3RK3 3RL0 7UDC 9CKX
GO Terms Enriched among Interactors ?	Organelle Localization By Membrane Tethering Membrane Docking Exocytosis SNARE Complex Secretion By Cell SNAP Receptor Activity Vesicle Docking Secretion Organelle Localization Vesicle Fusion SNARE Binding Organelle Membrane Fusion Membrane Fusion Vesicle-mediated Transport Synaptic Vesicle Membrane Organization Vesicle Organization Organelle Fusion Synaptic Vesicle Exocytosis Syntaxin-1 Binding Membrane Organization Regulated Exocytosis Vesicle Docking Involved In Exocytosis Signal Release Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane SNARE Complex Assembly Establishment Of Localization In Cell Membrane Regulation Of Secretion By Cell Establishment Of Protein Localization Calcium-ion Regulated Exocytosis Regulation Of Secretion Intracellular Protein Localization Protein Transport Cellular Localization Vesicle-mediated Transport In Synapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Neurotransmitter Transport Presynapse Regulation Of Exocytosis Specific Granule Regulation Of Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Presynaptic Dense Core Vesicle Exocytosis Hormone Secretion Insulin Secretion Syntaxin Binding Regulation Of Biological Quality Cytoplasmic Vesicle Neuron Projection