VAMP2 and VAMP3

Number of citations of the paper that reports this interaction (PMID 12130530)
33

Data Source:
BioGRID (pull down)

		VAMP2	VAMP3
Gene Name		vesicle-associated membrane protein 2 (synaptobrevin 2)	vesicle-associated membrane protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Membrane Cell Junction Clathrin-coated Vesicle Secretory Granule Secretory Granule Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Zymogen Granule Membrane Neuron Projection Intracellular Membrane-bounded Organelle Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Vesicular Exosome Clathrin-sculpted Monoamine Transport Vesicle Membrane	Intracellular Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Integral Component Of Membrane Apical Plasma Membrane Cell Junction Clathrin-coated Vesicle Secretory Granule Clathrin-coated Vesicle Membrane SNARE Complex Neuron Projection Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Protein Self-association Calcium-dependent Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin-1 Binding
	Biological Process	Energy Reserve Metabolic Process Protein Complex Assembly Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Glucose Glutamate Secretion Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium Ion-dependent Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Organization Membrane Fusion Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Histamine Secretion By Mast Cell	Positive Regulation Of Receptor Recycling Protein Complex Assembly Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Fusion Neurotransmitter Secretion Vesicle-mediated Transport Calcium Ion-dependent Exocytosis Substrate Adhesion-dependent Cell Spreading SNARE Complex Assembly Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Positive Regulation Of Immunoglobulin Secretion Membrane Fusion Mucus Secretion Negative Regulation Of Secretion By Cell Regulation Of Histamine Secretion By Mast Cell
Pathways		Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type D (BoNT/D) Golgi Associated Vesicle Biogenesis Translocation of GLUT4 to the plasma membrane GABA synthesis, release, reuptake and degradation Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins trans-Golgi Network Vesicle Budding Toxicity of botulinum toxin type G (BoNT/G) Regulation of insulin secretion Norepinephrine Neurotransmitter Release Cycle Toxicity of tetanus toxin (TeNT) Toxicity of botulinum toxin type F (BoNT/F) Glutamate Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Insulin processing Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Crohn's disease ( 21102463) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		26 interactors: ASNA1 ATP13A2 BAG6 BCAP31 CPLX1 FKBP2 PRKD3 RABAC1 SNAP23 SNAP25 SNAP29 STX11 STX1A STX1B STX2 STX3 STX4 STXBP2 STXBP3 SYP SYPL1 TRPC3 VAMP3 VAMP8 VAPA VAPB	14 interactors: ACAP1 APP BCAP31 BCL2L13 DDB1 IKBKG NELFE SNAP23 STX16 STX2 STX3 STX4 VAMP2 VAMP8
Entrez ID		6844	9341
HPRD ID		01717	04711
Ensembl ID		ENSG00000220205	ENSG00000049245
Uniprot IDs		F8WCA0 P63027	Q15836 Q6FGG2 Q9BRV4
PDB IDs		3FIE 3FII 3RK2 3RK3 3RL0
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Fusion Vesicle Organization Organelle Fusion Membrane Fusion Synaptic Vesicle Exocytosis Exocytosis Neurotransmitter Secretion Synaptic Vesicle Transport Vesicle Docking Membrane Organization Membrane Docking Regulation Of Neurotransmitter Levels Neurotransmitter Transport Secretion By Cell Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization Secretion Cellular Localization Establishment Of Organelle Localization Establishment Of Localization In Cell Cell-cell Signaling Transport Establishment Of Protein Localization Protein Localization Organelle Localization Synaptic Transmission Protein Transport Vesicle Docking Involved In Exocytosis Regulation Of Exocytosis Cell Communication Regulation Of Cellular Localization Signaling Organelle Organization Golgi Vesicle Transport Regulation Of Secretion Intracellular Transport Neutrophil Degranulation Cellular Protein Localization Synaptic Vesicle Docking SNARE Complex Assembly Regulation Of Vesicle-mediated Transport Neutrophil Activation Involved In Immune Response Synaptic Vesicle Priming Positive Regulation Of Synaptic Transmission Leukocyte Degranulation Regulated Secretory Pathway Regulation Of Synaptic Transmission Negative Regulation By Host Of Viral Genome Replication	Vesicle Fusion Organelle Fusion Membrane Fusion Vesicle Organization Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Vesicle Exocytosis Exocytosis Establishment Of Vesicle Localization Vesicle Localization Neurotransmitter Secretion Synaptic Vesicle Transport Golgi Vesicle Transport Secretion By Cell Establishment Of Localization In Cell Regulation Of Neurotransmitter Levels Protein Transport Vesicle-mediated Transport Establishment Of Organelle Localization Establishment Of Protein Localization Intracellular Transport Secretion Neurotransmitter Transport Cellular Localization Organelle Localization Vesicle Docking Post-Golgi Vesicle-mediated Transport Protein Localization Membrane Organization Membrane Docking Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane Intracellular Protein Transport Positive Regulation Of Protein Localization To Cell Surface SNARE Complex Assembly Synaptic Transmission Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization To Cell Surface Positive Regulation Of Regulated Secretory Pathway Cellular Protein Localization Transport Positive Regulation Of Peptidase Activity Response To Hydroperoxide Regulation Of Exocytosis Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Signaling Regulation Of Synaptic Plasticity Cell-cell Signaling Organelle Organization Positive Regulation Of Catalytic Activity Endoplasmic Reticulum Calcium Ion Homeostasis
Tagcloud ?		adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp1	cellubrevin coimmunoprecipitation consistent cytoplasmic deleted domains glut1 glut4 immunoprecipitation insulin introduction membrane microinjection neither plasma recombinant requirement responsive resulted site snap stimulated syntaxin translocation vaccinia vamp2 vesicle vesicles
Tagcloud (Difference) ?		adipocytes biol conjugate diaminobenzidine encompassing ethylmaleimide fill gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp1	coimmunoprecipitation consistent cytoplasmic deleted domains immunoprecipitation insulin introduction membrane microinjection neither plasma recombinant requirement responsive resulted site snap stimulated syntaxin translocation vaccinia vesicle vesicles
Tagcloud (Intersection) ?		cellubrevin glut1 glut4 vamp2