VAMP2 and PRKD3

Number of citations of the paper that reports this interaction (PMID 17196367)
10

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		VAMP2	PRKD3
Gene Name		vesicle-associated membrane protein 2 (synaptobrevin 2)	protein kinase D3
Image
Gene Ontology Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Membrane Cell Junction Clathrin-coated Vesicle Secretory Granule Secretory Granule Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Zymogen Granule Membrane Neuron Projection Intracellular Membrane-bounded Organelle Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Vesicular Exosome Clathrin-sculpted Monoamine Transport Vesicle Membrane	Nucleoplasm Cytoplasm Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Protein Self-association Calcium-dependent Protein Binding	Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Energy Reserve Metabolic Process Protein Complex Assembly Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Glucose Glutamate Secretion Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium Ion-dependent Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Organization Membrane Fusion Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Histamine Secretion By Mast Cell	Protein Phosphorylation Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction
Pathways		Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type D (BoNT/D) Golgi Associated Vesicle Biogenesis Translocation of GLUT4 to the plasma membrane GABA synthesis, release, reuptake and degradation Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins trans-Golgi Network Vesicle Budding Toxicity of botulinum toxin type G (BoNT/G) Regulation of insulin secretion Norepinephrine Neurotransmitter Release Cycle Toxicity of tetanus toxin (TeNT) Toxicity of botulinum toxin type F (BoNT/F) Glutamate Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Insulin processing Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ASNA1 ATP13A2 BAG6 BCAP31 CPLX1 FKBP2 PRKD3 RABAC1 SNAP23 SNAP25 SNAP29 STX11 STX1A STX1B STX2 STX3 STX4 STXBP2 STXBP3 SYP SYPL1 TRPC3 VAMP3 VAMP8 VAPA VAPB	9 interactors: BCL6 DLAT GSK3A IKBKG KPNA2 KPNB1 NUDT3 SKA2 VAMP2
Entrez ID		6844	23683
HPRD ID		01717	06151
Ensembl ID		ENSG00000220205	ENSG00000115825
Uniprot IDs		F8WCA0 P63027	O94806
PDB IDs		3FIE 3FII 3RK2 3RK3 3RL0	2D9Z
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Fusion Vesicle Organization Organelle Fusion Membrane Fusion Synaptic Vesicle Exocytosis Exocytosis Neurotransmitter Secretion Synaptic Vesicle Transport Vesicle Docking Membrane Organization Membrane Docking Regulation Of Neurotransmitter Levels Neurotransmitter Transport Secretion By Cell Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization Secretion Cellular Localization Establishment Of Organelle Localization Establishment Of Localization In Cell Cell-cell Signaling Transport Establishment Of Protein Localization Protein Localization Organelle Localization Synaptic Transmission Protein Transport Vesicle Docking Involved In Exocytosis Regulation Of Exocytosis Cell Communication Regulation Of Cellular Localization Signaling Organelle Organization Golgi Vesicle Transport Regulation Of Secretion Intracellular Transport Neutrophil Degranulation Cellular Protein Localization Synaptic Vesicle Docking SNARE Complex Assembly Regulation Of Vesicle-mediated Transport Neutrophil Activation Involved In Immune Response Synaptic Vesicle Priming Positive Regulation Of Synaptic Transmission Leukocyte Degranulation Regulated Secretory Pathway Regulation Of Synaptic Transmission Negative Regulation By Host Of Viral Genome Replication	Protein Import Into Nucleus Nuclear Import Protein Import NLS-bearing Protein Import Into Nucleus Protein Localization To Nucleus Protein Import Into Nucleus, Translocation Cytoplasmic Transport Nucleocytoplasmic Transport Nuclear Transport Energy Derivation By Oxidation Of Organic Compounds Intracellular Protein Transport Establishment Of Protein Localization To Organelle Regulation Of DNA Recombination Negative Regulation Of UDP-glucose Catabolic Process Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Establishment Of Localization In Cell Negative Regulation Of Intracellular Signal Transduction Generation Of Precursor Metabolites And Energy Protein Targeting Protein Localization To Organelle Negative Regulation Of Type B Pancreatic Cell Development Immune Response Viral Process Cellular Localization Signaling Cellular Protein Localization Cell Communication Cellular Response To Cytokine Stimulus Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Eosinophil Degranulation Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Isotype Switching To IgE Isotypes Energy Reserve Metabolic Process Protein Transport Establishment Of Protein Localization Hypermethylation Of CpG Island Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Cell Growth Intracellular Transport Positive Regulation Of Glycogen (starch) Synthase Activity Cellular Response To Interleukin-3 Response To Cytokine Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Establishment Of Vesicle Localization
Tagcloud ?		adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp1	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate profiled profiling proteomics regard runx1 runx2 satb2 tcf3 testis yap1
Tagcloud (Difference) ?		adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp1	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate profiled profiling proteomics regard runx1 runx2 satb2 tcf3 testis yap1
Tagcloud (Intersection) ?