VAMP2 and VAPA

Number of citations of the paper that reports this interaction (PMID 9657962)
22

Data Source:
HPRD (in vitro)

		VAMP2	VAPA
Gene Name		vesicle-associated membrane protein 2 (synaptobrevin 2)	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
Image
Gene Ontology Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Membrane Cell Junction Clathrin-coated Vesicle Secretory Granule Secretory Granule Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Zymogen Granule Membrane Neuron Projection Intracellular Membrane-bounded Organelle Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Vesicular Exosome Clathrin-sculpted Monoamine Transport Vesicle Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Protein Self-association Calcium-dependent Protein Binding	Signal Transducer Activity Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Heterodimerization Activity
	Biological Process	Energy Reserve Metabolic Process Protein Complex Assembly Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Glucose Glutamate Secretion Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium Ion-dependent Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Organization Membrane Fusion Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Histamine Secretion By Mast Cell	Sphingolipid Metabolic Process ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Signal Transduction Cell Death Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding
Pathways		Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type D (BoNT/D) Golgi Associated Vesicle Biogenesis Translocation of GLUT4 to the plasma membrane GABA synthesis, release, reuptake and degradation Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins trans-Golgi Network Vesicle Budding Toxicity of botulinum toxin type G (BoNT/G) Regulation of insulin secretion Norepinephrine Neurotransmitter Release Cycle Toxicity of tetanus toxin (TeNT) Toxicity of botulinum toxin type F (BoNT/F) Glutamate Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Insulin processing Transmission across Chemical Synapses	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		26 interactors: ASNA1 ATP13A2 BAG6 BCAP31 CPLX1 FKBP2 PRKD3 RABAC1 SNAP23 SNAP25 SNAP29 STX11 STX1A STX1B STX2 STX3 STX4 STXBP2 STXBP3 SYP SYPL1 TRPC3 VAMP3 VAMP8 VAPA VAPB	15 interactors: ADRB2 APOD APP CACNG1 EGFR GPR128 NSF OPRM1 OSBP RMDN3 SIK1 VAMP1 VAMP2 VAPB ZBTB22
Entrez ID		6844	9218
HPRD ID		01717	09299
Ensembl ID		ENSG00000220205	ENSG00000101558
Uniprot IDs		F8WCA0 P63027	Q9P0L0
PDB IDs		3FIE 3FII 3RK2 3RK3 3RL0	2RR3
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Fusion Vesicle Organization Organelle Fusion Membrane Fusion Synaptic Vesicle Exocytosis Exocytosis Neurotransmitter Secretion Synaptic Vesicle Transport Vesicle Docking Membrane Organization Membrane Docking Regulation Of Neurotransmitter Levels Neurotransmitter Transport Secretion By Cell Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization Secretion Cellular Localization Establishment Of Organelle Localization Establishment Of Localization In Cell Cell-cell Signaling Transport Establishment Of Protein Localization Protein Localization Organelle Localization Synaptic Transmission Protein Transport Vesicle Docking Involved In Exocytosis Regulation Of Exocytosis Cell Communication Regulation Of Cellular Localization Signaling Organelle Organization Golgi Vesicle Transport Regulation Of Secretion Intracellular Transport Neutrophil Degranulation Cellular Protein Localization Synaptic Vesicle Docking SNARE Complex Assembly Regulation Of Vesicle-mediated Transport Neutrophil Activation Involved In Immune Response Synaptic Vesicle Priming Positive Regulation Of Synaptic Transmission Leukocyte Degranulation Regulated Secretory Pathway Regulation Of Synaptic Transmission Negative Regulation By Host Of Viral Genome Replication	Metal Ion Homeostasis Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Localization Exocytosis Membrane Fusion Cellular Metal Ion Homeostasis Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Homeostatic Process Membrane Organization Cellular Cation Homeostasis Chemical Homeostasis Cellular Ion Homeostasis Vesicle-mediated Transport Transport Intracellular Transport Golgi To Plasma Membrane Transport Secretion By Cell Cellular Chemical Homeostasis Vesicle Organization Regulation Of Cellular Localization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Vasodilation Establishment Of Protein Localization To Membrane Vesicle Fusion Regulation Of Ion Transport Regulation Of Protein Transport Secretion Regulation Of Intracellular Protein Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Golgi Vesicle Transport Regulation Of Adenylate Cyclase Activity Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Wnt Protein Secretion Alkanesulfonate Metabolic Process Negative Regulation Of T Cell Migration Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation By Host Of Viral Release From Host Cell Cytoplasmic Transport Cellular Homeostasis Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp1	abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular
Tagcloud (Difference) ?		adipocytes biol cellubrevin conjugate diaminobenzidine encompassing ethylmaleimide fill glut1 glut4 gould gst guanosine horseradish itinerant james livingstone localizes martin permeabilized postendocytic slot snares streptolysin tails tellam thio triphosphate vamp1	abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular
Tagcloud (Intersection) ?