TRPC3 and NAPA

Number of citations of the paper that reports this interaction (PubMedID 15327778)
0

Data Source:
HPRD (two hybrid, in vivo)

		TRPC3	NAPA
Description		transient receptor potential cation channel subfamily C member 3	NSF attachment protein alpha
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cation Channel Complex	Cytosol Plasma Membrane Membrane Neuromuscular Junction Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding	SNARE Binding Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding Protein-containing Complex Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Brain Development Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Vesicle-mediated Transport Neuron Differentiation Protein-containing Complex Disassembly Synaptic Transmission, Glutamatergic SNARE Complex Disassembly Apical Protein Localization Membrane Fusion
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels	COPII-mediated vesicle transport Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Asthma ( 31959851 34103634) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)	Blood protein levels ( 30072576)
Interacting Genes		21 interacting genes: CALM1 FKBP1A FNDC5 GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2	22 interacting genes: APP BNIP1 DSCAM FURIN GNA12 GOSR1 GOSR2 HSPB1 HUNK NSF RIPK4 RTN4 SNAP23 SNAP25 STX12 STX1A STX4 STX5 STX7 STX8 TRPC3 VAMP8
Entrez ID		7222	8775
HPRD ID		15999	04447
Ensembl ID		ENSG00000138741	ENSG00000105402
Uniprot IDs		Q13507	P54920
PDB IDs		5ZBG 6CUD 6D7L 6DJS 7DXB 7DXC 7DXD 7DXE
Enriched GO Terms of Interacting Partners?		Regulation Of Sequestering Of Calcium Ion Calcium Ion Transmembrane Transport Calcium Ion Transport Metal Ion Transport Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Phosphatidylinositol Phospholipase C Activity Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Ion Transport Inorganic Ion Transmembrane Transport Store-operated Calcium Channel Activity Monoatomic Ion Transmembrane Transport Calcium Channel Activity Calcium-mediated Signaling Phospholipase C Activity Regulation Of Metal Ion Transport Regulation Of Transport Regulation Of Calcium Ion Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Plasma Membrane Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Calcium Ion Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Positive Regulation Of Transport Calcium Ion Binding Phosphoric Diester Hydrolase Activity Intracellular Signaling Cassette Positive Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Protein Localization Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion	SNAP Receptor Activity SNARE Complex Organelle Membrane Fusion Membrane Fusion Organelle Fusion Vesicle Fusion SNARE Binding Membrane Organization Organelle Localization By Membrane Tethering Vesicle Organization Membrane Docking Vesicle Docking Vesicle-mediated Transport Establishment Of Localization In Cell Chloride Channel Inhibitor Activity Protein Transport Syntaxin Binding Establishment Of Protein Localization Secretion By Cell Endomembrane System Intracellular Protein Localization Organelle Localization Intracellular Transport Vesicle Neuron Projection Secretion Exocytosis Intracellular Protein Transport SNARE Complex Assembly Recycling Endosome Cellular Localization Golgi Vesicle Transport Plasma Membrane Endosome Organelle Organization Membrane Neurotransmitter Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Intra-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Neuron Recognition Modulation Of Chemical Synaptic Transmission Positive Regulation Of Chemotaxis Positive Regulation Of Synaptic Transmission Positive Regulation Of Regulated Secretory Pathway Protein-containing Complex Organization Heparan Sulfate Binding Regulation Of Protein Localization To Cell Periphery
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