VAMP2 and STXBP3

Number of citations of the paper that reports this interaction (PubMedID 12832401)
0

Data Source:
BioGRID (pull down)

		VAMP2	STXBP3
Description		vesicle associated membrane protein 2	syntaxin binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Vesicle Zymogen Granule Membrane Neuron Projection Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Clathrin-sculpted Monoamine Transport Vesicle Membrane	Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Platelet Alpha Granule Specific Granule Phagocytic Vesicle Extracellular Exosome Tertiary Granule Presynapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding	Protein Binding Syntaxin-1 Binding Syntaxin Binding Protein-containing Complex Binding
	Biological Process	Exocytosis Vesicle Fusion Response To Glucose Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Synaptic Vesicle Endocytosis Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Histamine Secretion By Mast Cell	Intracellular Glucose Homeostasis Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Response To Stress Immune Response Brain Development Protein Transport Vesicle-mediated Transport Protein To Membrane Docking Insulin Secretion Response To Insulin Neutrophil Degranulation Regulated Exocytosis Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of D-glucose Import Negative Regulation Of Transport Regulation Of Biological Quality Platelet Aggregation Cellular Response To Type II Interferon Presynaptic Dense Core Vesicle Exocytosis
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle trans-Golgi Network Vesicle Budding Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Other interleukin signaling Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type F (botF) Toxicity of tetanus toxin (tetX) Toxicity of botulinum toxin type G (botG) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea	Disinhibition of SNARE formation Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs		Botulinum toxin type B
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Morning person ( 30696823) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Fat distribution (HIV) ( 21897333)
Interacting Genes		47 interacting genes: AQP6 ARL13B ATP13A2 BAG6 BCAP31 CERS4 CPLX1 CREB3L1 EBP ERGIC3 EXOC3 FKBP2 GET3 HIBADH HSD17B13 JAGN1 KASH5 LMNA MARCHF8 PRKD3 RABAC1 SCN3B SLC30A8 SLC6A4 SLC7A14 SNAP23 SNAP25 SNCA STX11 STX1A STX1B STX2 STX4 STXBP2 STXBP3 SYP SYPL1 TMEM101 TMEM31 TMEM86B TRPC3 VAMP3 VAMP8 VAPA VAPB VCP VMA21	15 interacting genes: DDX20 GEMIN2 GEMIN4 GEMIN5 PRKCA RPL3 SMN1 SNCA SNRPB SNRPD2 SNRPD3 SNTG1 STX4 STXBP2 VAMP2
Entrez ID		6844	6814
HPRD ID		01717	10517
Ensembl ID		ENSG00000220205	ENSG00000116266
Uniprot IDs		F8WCA0 P63027	O00186
PDB IDs		3FIE 3FII 3RK2 3RK3 3RL0 7UDC 9CKX
Enriched GO Terms of Interacting Partners?		Organelle Localization By Membrane Tethering Membrane Docking Exocytosis SNARE Complex Secretion By Cell SNAP Receptor Activity Vesicle Docking Secretion Organelle Localization Vesicle Fusion SNARE Binding Organelle Membrane Fusion Membrane Fusion Vesicle-mediated Transport Synaptic Vesicle Membrane Organization Vesicle Organization Organelle Fusion Synaptic Vesicle Exocytosis Syntaxin-1 Binding Membrane Organization Regulated Exocytosis Vesicle Docking Involved In Exocytosis Signal Release Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane SNARE Complex Assembly Establishment Of Localization In Cell Membrane Regulation Of Secretion By Cell Establishment Of Protein Localization Calcium-ion Regulated Exocytosis Regulation Of Secretion Intracellular Protein Localization Protein Transport Cellular Localization Vesicle-mediated Transport In Synapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Neurotransmitter Transport Presynapse Regulation Of Exocytosis Specific Granule Regulation Of Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Presynaptic Dense Core Vesicle Exocytosis Hormone Secretion Insulin Secretion Syntaxin Binding Regulation Of Biological Quality Cytoplasmic Vesicle Neuron Projection	SMN-Sm Protein Complex Spliceosomal SnRNP Assembly SMN Complex Gemini Of Cajal Bodies Protein-RNA Complex Assembly RNA Splicing Protein-containing Complex Assembly Spliceosomal Complex Assembly Small Nuclear Ribonucleoprotein Complex MRNA Processing Protein-containing Complex Organization MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Cellular Component Assembly 7-methylguanosine Cap Hypermethylation U4 SnRNP SNARE Complex Assembly Methylosome RNA Processing Regulation Of Exocytosis Nuclear Body U1 SnRNP U5 SnRNP Cytosol U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2 SnRNP U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Synaptic Vesicle Exocytosis Histone Pre-mRNA DCP Binding U4/U6 X U5 Tri-snRNP Complex RNA Metabolic Process U2-type Precatalytic Spliceosome PICln-Sm Protein Complex Long-term Synaptic Potentiation Spliceosomal Complex U7 SnRNP Neutrophil Degranulation SNARE Binding MRNA Splicing, Via Spliceosome Exocytosis RNA Methylation Positive Regulation Of Exocytosis Catalytic Step 2 Spliceosome Specific Granule Vesicle-mediated Transport In Synapse Response To Cytokine Regulation Of Vesicle-mediated Transport Response To Peptide
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