TRPC3 and GNA11

Number of citations of the paper that reports this interaction (PMID 11524429)
23

Data Source:
HPRD (in vivo)

		TRPC3	GNA11
Gene Name		transient receptor potential cation channel, subfamily C, member 3	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Calcium Ion Transport Axon Guidance Blood Coagulation Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Skeletal System Development Action Potential Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Heart Development Blood Coagulation Platelet Activation Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH
Pathways		G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2	17 interactors: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A PTGIR RGS14 RGS3 SLC9A3R1 TBXA2R TRPC3 TSHR
Entrez ID		7222	2767
HPRD ID		15999	00759
Ensembl ID		ENSG00000138741
Uniprot IDs		J3QTB0 Q13507	P29992
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Activation Of Phospholipase C Activity Calcium Ion Transmembrane Transport Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Cell Activation Regulation Of Phospholipase Activity Calcium Ion Transport Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Platelet Activation Inositol Phosphate Metabolic Process Second-messenger-mediated Signaling Cellular Calcium Ion Homeostasis Regulation Of Ion Homeostasis Calcium Ion Homeostasis Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Synaptic Transmission Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Metal Ion Homeostasis Energy Reserve Metabolic Process Cellular Chemical Homeostasis Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Metal Ion Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Ion Homeostasis Chemical Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Signaling Response To Stimulus Cation Transmembrane Transport Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ion Transport Response To Fibroblast Growth Factor Regulation Of Calcium Ion Transport Into Cytosol	G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Vasoconstriction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Blood Circulation Cytosolic Calcium Ion Homeostasis Ion Homeostasis Chemical Homeostasis Regulation Of MAPK Cascade Regulation Of Phosphorylation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Homeostatic Process Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Phosphorylation Signal Transduction Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Cellular Chemical Homeostasis Signaling Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Cellular Metal Ion Homeostasis Cellular Homeostasis Cellular Cation Homeostasis Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction Regulation Of Ion Homeostasis Vascular Smooth Muscle Contraction Regulation Of Blood Pressure Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Abiotic Stimulus Regulation Of Signal Transduction Muscle Contraction Regulation Of CAMP Biosynthetic Process Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Response To Stimulus Endothelin Receptor Signaling Pathway
Tagcloud ?		channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1	amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina
Tagcloud (Difference) ?		channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1	amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina
Tagcloud (Intersection) ?