TRPC3 and MX1

Number of citations of the paper that reports this interaction (PubMedID 15757897)
0

Data Source:
HPRD (in vivo, in vitro)

		TRPC3	MX1
Description		transient receptor potential cation channel subfamily C member 3	MX dynamin like GTPase 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Cation Channel Complex	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Microtubule Plasma Membrane Membrane Nuclear Membrane Synapse Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Immune System Process Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Interleukin-27-mediated Signaling Pathway Antiviral Innate Immune Response
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Asthma ( 31959851 34103634) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)
Interacting Genes		21 interacting genes: CALM1 FKBP1A FNDC5 GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2	42 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA FXR1 GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623
Entrez ID		7222	4599
HPRD ID		15999	00919
Ensembl ID		ENSG00000138741	ENSG00000157601
Uniprot IDs		Q13507	H9KVC7 P20591
PDB IDs		5ZBG 6CUD 6D7L 6DJS 7DXB 7DXC 7DXD 7DXE	3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM
Enriched GO Terms of Interacting Partners?		Regulation Of Sequestering Of Calcium Ion Calcium Ion Transmembrane Transport Calcium Ion Transport Metal Ion Transport Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Phosphatidylinositol Phospholipase C Activity Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Ion Transport Inorganic Ion Transmembrane Transport Store-operated Calcium Channel Activity Monoatomic Ion Transmembrane Transport Calcium Channel Activity Calcium-mediated Signaling Phospholipase C Activity Regulation Of Metal Ion Transport Regulation Of Transport Regulation Of Calcium Ion Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Plasma Membrane Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Calcium Ion Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Positive Regulation Of Transport Calcium Ion Binding Phosphoric Diester Hydrolase Activity Intracellular Signaling Cassette Positive Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Protein Localization Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion	Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex PML Body Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Transcription Corepressor Activity Cytoplasmic Ribonucleoprotein Granule SUMO Ligase Activity Actinin Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Monoatomic Ion Channel Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis SUMO Transferase Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Calcium Ion Transport Regulation Of Cytokine Production Involved In Inflammatory Response Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Development Regulation Of T Cell Activation Identical Protein Binding Regulation Of T Cell Differentiation Intracellular Monoatomic Cation Homeostasis Associative Learning Inorganic Ion Homeostasis Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Protein Homodimerization Activity Intracellular Monoatomic Ion Homeostasis Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Envelope Lumen SUMO Binding Synapse Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing
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