TRPC3 and PLCB1

Number of citations of the paper that reports this interaction (PMID 15623527)
19

Data Source:
HPRD (in vivo)

		TRPC3	PLCB1
Gene Name		transient receptor potential cation channel, subfamily C, member 3	phospholipase C, beta 1 (phosphoinositide-specific)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nuclear Chromatin Nucleus Cytoplasm Cytosol Nuclear Speck Nuclear Membrane Extracellular Vesicular Exosome
	Molecular Function	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding	Phosphatidylinositol Phospholipase C Activity Signal Transducer Activity GTPase Activator Activity Calcium Ion Binding Calmodulin Binding Lamin Binding Phosphatidylinositol-4,5-bisphosphate Binding Enzyme Binding Protein Homodimerization Activity
	Biological Process	Calcium Ion Transport Axon Guidance Blood Coagulation Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	G2/M Transition Of Mitotic Cell Cycle Signal Transduction G-protein Coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Synaptic Transmission Memory Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Lipid Catabolic Process Cerebral Cortex Development Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Fat Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Phosphatidylinositol Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Developmental Growth Activation Of Meiosis Involved In Egg Activation Interleukin-1-mediated Signaling Pathway Regulation Of Fertilization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Acrosome Reaction Negative Regulation Of Monocyte Extravasation Positive Regulation Of CD24 Biosynthetic Process
Pathways		G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling	G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Cognitive performance ( 20125193 19734545) Colorectal cancer ( 23263487) Response to irinotecan in non-small-cell lung cancer ( 22664479)
Protein-Protein Interactions		20 interactors: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2	17 interactors: CEP76 CTBP1 CTBP2 GNAQ MAPK1 MAPK3 PARD3 PARD6A PRKCA PRKCD RGS12 RGS4 SLC9A3R1 SPTBN1 TFCP2 TRPC3 TRPM7
Entrez ID		7222	23236
HPRD ID		15999	06177
Ensembl ID		ENSG00000138741	ENSG00000182621
Uniprot IDs		J3QTB0 Q13507	Q9NQ66
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Activation Of Phospholipase C Activity Calcium Ion Transmembrane Transport Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Cell Activation Regulation Of Phospholipase Activity Calcium Ion Transport Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Platelet Activation Inositol Phosphate Metabolic Process Second-messenger-mediated Signaling Cellular Calcium Ion Homeostasis Regulation Of Ion Homeostasis Calcium Ion Homeostasis Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Synaptic Transmission Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Metal Ion Homeostasis Energy Reserve Metabolic Process Cellular Chemical Homeostasis Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Metal Ion Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Ion Homeostasis Chemical Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Signaling Response To Stimulus Cation Transmembrane Transport Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ion Transport Response To Fibroblast Growth Factor Regulation Of Calcium Ion Transport Into Cytosol	Platelet Activation Wound Healing Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Wounding Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of MAP Kinase Activity Cell Cycle Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Regulation Of Golgi Inheritance Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Negative Regulation Of MAPK Cascade Caveolin-mediated Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Cell Activation Peptidyl-threonine Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Phospholipase C Activity Response To Fibroblast Growth Factor Regulation Of Golgi Organization Negative Regulation Of Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of Protein Kinase Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Neurotrophin Signaling Pathway Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Kinase Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Phospholipase Activity Negative Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Tagcloud ?		channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1	450k arrays cdkn2a deregulated epigenomic exome fate gabrb3 harboring hnscc hoxc12 hoxc6 inactivated mbd parp15 pax pax1 pax5 pik3ap1 pursued seq slco4c1 somatic throughput tsgs uncovered uppps uvulopalatopharyngoplasty zic4
Tagcloud (Difference) ?		channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1	450k arrays cdkn2a deregulated epigenomic exome fate gabrb3 harboring hnscc hoxc12 hoxc6 inactivated mbd parp15 pax pax1 pax5 pik3ap1 pursued seq slco4c1 somatic throughput tsgs uncovered uppps uvulopalatopharyngoplasty zic4
Tagcloud (Intersection) ?