TRPC3 and TRPC1

Number of citations of the paper that reports this interaction (PubMedID 12032305)
37

Data Source:
HPRD (in vivo)

		TRPC3	TRPC1
Description		transient receptor potential cation channel subfamily C member 3	transient receptor potential cation channel subfamily C member 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Cation Channel Complex	Plasma Membrane Membrane Cation Channel Complex Receptor Complex
	Molecular Function	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding	Signaling Receptor Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Transmembrane Transporter Binding Metal Ion Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Melanin Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Conduction
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels	TRP channels Role of second messengers in netrin-1 signaling Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Asthma ( 31959851 34103634) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)
Interacting Genes		21 interacting genes: CALM1 FKBP1A FNDC5 GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2	14 interacting genes: BMPR2 CAV1 GRIA1 HOMER1 HOMER3 ITPR2 ITPR3 MDFI MX1 PKD2 RHOA TRPC3 TRPC4 TRPC5
Entrez ID		7222	7220
HPRD ID		15999	11894
Ensembl ID		ENSG00000138741	ENSG00000144935
Uniprot IDs		Q13507	P48995
PDB IDs		5ZBG 6CUD 6D7L 6DJS 7DXB 7DXC 7DXD 7DXE	8WPL 8WPM
Enriched GO Terms of Interacting Partners?		Regulation Of Sequestering Of Calcium Ion Calcium Ion Transmembrane Transport Calcium Ion Transport Metal Ion Transport Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Phosphatidylinositol Phospholipase C Activity Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Ion Transport Inorganic Ion Transmembrane Transport Store-operated Calcium Channel Activity Monoatomic Ion Transmembrane Transport Calcium Channel Activity Calcium-mediated Signaling Phospholipase C Activity Regulation Of Metal Ion Transport Regulation Of Transport Regulation Of Calcium Ion Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Plasma Membrane Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Calcium Ion Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Positive Regulation Of Transport Calcium Ion Binding Phosphoric Diester Hydrolase Activity Intracellular Signaling Cassette Positive Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Protein Localization Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion	Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Calcium Ion Transport Cation Channel Complex Monoatomic Ion Channel Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Response To Calcium Ion Store-operated Calcium Channel Activity Regulation Of Cytosolic Calcium Ion Concentration Response To Metal Ion Monoatomic Ion Transport Metal Ion Transport Plasma Membrane Intracellular Calcium Ion Homeostasis Regulation Of Monoatomic Ion Transport Inorganic Ion Homeostasis Regulation Of Calcium Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Dendrite Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity G Protein-coupled Glutamate Receptor Binding Transmembrane Transporter Binding Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Muscle Tissue Development Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Metal Ion Transport Endoplasmic Reticulum Membrane Calcium-mediated Signaling Glutamate Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Transmembrane Transport Intracellular Monoatomic Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Neuron Spine Regulation Of Vasoconstriction Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Caveola Intracellular Signaling Cassette Chemical Homeostasis Signal Transduction ATPase Binding Postsynaptic Density
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