THAP7 and TAF1B

Number of citations of the paper that reports this interaction (PMID 15561719)
19

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		THAP7	TAF1B
Gene Name		THAP domain containing 7	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome Nuclear Speck	Nucleus Nucleoplasm Extracellular Vesicular Exosome RNA Polymerase I Core Factor Complex
	Molecular Function	DNA Binding Metal Ion Binding Protein N-terminus Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase I CORE Element Sequence-specific DNA Binding RNA Polymerase I CORE Element Sequence-specific DNA Binding Transcription Factor Recruiting Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding TBP-class Protein Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Chromatin Silencing At RDNA RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Transcription, DNA-templated Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways			NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression SIRT1 negatively regulates rRNA Expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		34 interactors: APP CCDC85B CCNDBP1 EHMT2 GNAI1 GOLGA2 HCFC1 HDAC3 HIST1H3A HIST1H4A KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP4-12 LNX1 LURAP1 LZTS2 MAP1LC3B MDFI MID2 MTUS2 NOTCH2NL PELI2 PHC2 PIN1 PPP3CC SET TAF1B TFIP11 THAP11 TRAF1 TRAF2 ZDHHC17	24 interactors: APP EP300 ESR1 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE MYC NAPB NEDD4 NEDD4L PGR RRN3 RXRA SRPK1 TAF1A TAF1C TAF1D TBP THAP7 TP53 TRB TRIM24 UBTF
Entrez ID		80764	9014
HPRD ID		15500	05363
Ensembl ID		ENSG00000184436	ENSG00000115750
Uniprot IDs		Q9BT49	Q53T94
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Negative Regulation Of RNA Biosynthetic Process Cellular Component Assembly Chromatin Silencing At RDNA Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Silencing Protein Complex Assembly Regulation Of Transcription, DNA-templated Positive Regulation Of Intracellular Signal Transduction Regulation Of Nucleic Acid-templated Transcription Regulation Of Signal Transduction Regulation Of RNA Biosynthetic Process Protein-DNA Complex Assembly DNA Methylation Regulation Of RNA Metabolic Process DNA Replication-dependent Nucleosome Assembly Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Cellular Macromolecular Complex Assembly Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Regulation Of Signaling DNA Modification Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Gene Expression Chromatin Organization Regulation Of Nitrogen Compound Metabolic Process Regulation Of Binding Regulation Of Cellular Process Gene Silencing Nucleosome Assembly Positive Regulation Of NF-kappaB Transcription Factor Activity Chromatin Assembly Notch Signaling Pathway Nucleosome Organization Regulation Of MAPK Cascade Regulation Of Protein Binding Cellular Protein Modification Process Regulation Of Intracellular Signal Transduction Chromatin Assembly Or Disassembly Histone H3-K9 Modification Regulation Of JNK Cascade Chromosome Organization Histone Modification Spliceosomal Complex Disassembly	Negative Regulation Of Gene Expression DNA-templated Transcription, Initiation Chromatin Silencing At RDNA Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Transcription Initiation From RNA Polymerase I Promoter Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase I Promoter Negative Regulation Of Gene Expression, Epigenetic Gene Expression Chromatin Silencing Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase I Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Transcription Elongation From RNA Polymerase I Promoter Regulation Of RNA Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Silencing Regulation Of Gene Expression, Epigenetic Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Termination Positive Regulation Of Transcription, DNA-templated Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization Viral Process DNA Packaging Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Biosynthetic Process DNA Conformation Change
Tagcloud ?		15b belonging c2ch caenorhabditis chelator consensus coordinating cx dap4 defines e2f6 elegans evolutionarily histidine lin list orthologue phenanthroline proapoptotic repressor segregation similarities superfamily thap0 thap1 transposase uncharacterized zinc	analysed blocking c8 coding crc frameshift gc harboured heterogeneity instability intratumoural ith microsatellite mononucleotide msi mss mutational regional ribosomal rrna somatic strand summary taf1a taf1c tata tbp tumourigenesis ubf
Tagcloud (Difference) ?		15b belonging c2ch caenorhabditis chelator consensus coordinating cx dap4 defines e2f6 elegans evolutionarily histidine lin list orthologue phenanthroline proapoptotic repressor segregation similarities superfamily thap0 thap1 transposase uncharacterized zinc	analysed blocking c8 coding crc frameshift gc harboured heterogeneity instability intratumoural ith microsatellite mononucleotide msi mss mutational regional ribosomal rrna somatic strand summary taf1a taf1c tata tbp tumourigenesis ubf
Tagcloud (Intersection) ?