THAP7 and PHF19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		THAP7	PHF19
Description		THAP domain containing 7	PHD finger protein 19
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Speck Nuclear Membrane	Nucleus Nucleoplasm ESC/E(Z) Complex
	Molecular Function	Transcription Corepressor Binding DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding Histone H4 Reader Activity General Transcription Initiation Factor Binding Histone Reader Activity	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3K36me3 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Stem Cell Population Maintenance Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Stem Cell Differentiation
Pathways			PRC2 methylates histones and DNA
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Birth weight ( 27680694 31043758) Corneal astigmatism ( 29422769) High density lipoprotein cholesterol levels ( 29403010) Prostate-specific antigen levels ( 28139693) Pulse pressure ( 27618448 28135244) Refractive error ( 32231278)
Interacting Genes		63 interacting genes: ANKRD28 APP CCDC136 CCDC85B CCNDBP1 CDC37 CYSRT1 DESI2 DVL3 EFEMP2 EHMT2 FBXO7 FHL3 FSD2 GABARAPL1 GNAI1 GOLGA2 GOLGA6L9 H3C1 H4C1 HCFC1 HDAC3 HOXA1 KRT27 KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP17-1 KRTAP4-12 LDOC1 LNX1 LURAP1 LZTS2 MAGOHB MAP1LC3B MCC MDFI MID2 MTUS2 NBPF19 NOTCH2NLA NTAQ1 PELI2 PHC2 PHF19 PICK1 PIN1 PNMA2 PPP3CC SET TAF1B TFIP11 THAP11 TLE5 TPM3 TRAF1 TRAF2 TRAF5 ZDHHC17 ZRANB1	22 interacting genes: BAG4 BTRC CSNK2A1 DVL3 H3C1 HOMEZ HOXB5 INO80E KDM1A LZTS2 PICK1 POTEB3 RCOR3 SNIP1 SUV39H1 SUV39H2 THAP1 THAP7 TSPYL2 YTHDC1 ZNF837 ZRANB1
Entrez ID		80764	26147
HPRD ID		15500	17846
Ensembl ID		ENSG00000184436	ENSG00000119403
Uniprot IDs		Q9BT49	A0A087X169 B7Z887 B7Z8H3 F5H8K3 Q5T6S3
PDB IDs			2E5Q 4BD3 6NQ3 6WAU
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Thioesterase Binding Protein Binding Regulation Of Wnt Signaling Pathway Regulation Of JNK Cascade Regulation Of Toll Signaling Pathway Cytosol Intermediate Filament Organization Protein-containing Complex Disassembly Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Wnt Signaling Pathway Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Protein Serine/threonine Phosphatase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Nitrogen Starvation Cytoskeleton CD40 Receptor Complex	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Chromatin Organization Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Chromatin Negative Regulation Of Metabolic Process Nucleus Histone H3K9 Methyltransferase Activity Epigenetic Programming In The Zygotic Pronuclei Regulation Of DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Histone H3 Methyltransferase Activity Cellular Component Assembly Regulation Of Wnt Signaling Pathway Cellular Response To Decreased Oxygen Levels Epigenetic Programming Of Gene Expression Histone Methyltransferase Activity Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen Levels Negative Regulation Of MRNA Modification Primary Ureteric Bud Growth Regulation Of Protein Stability Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Signal Transduction By P53 Class Mediator Chromosome Cellular Response To Glucose Starvation Regulation Of Cell Communication Regulation Of Signaling
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