TMOD1 and ODC1

Number of citations: 0 (PubMedID 24412244)
Data Source: BioGRID (two hybrid)

		TMOD1	ODC1
Name		tropomodulin 1	ornithine decarboxylase 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament COP9 Signalosome Membrane Myofibril Sarcomere Cortical Cytoskeleton	Cytoplasm Cytosol
	Molecular Function	Actin Binding Tropomyosin Binding	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity Protein Homodimerization Activity
	Biological Process	Muscle Contraction Actin Filament Organization Adult Locomotory Behavior Myofibril Assembly Pointed-end Actin Filament Capping Lens Fiber Cell Development	Kidney Development Polyamine Metabolic Process Polyamine Biosynthetic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Virus Putrescine Biosynthetic Process From Arginine, Via Ornithine Regulation Of Protein Catabolic Process
Pathways		Striated Muscle Contraction	Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines
Drugs		None	Pyridoxal phosphate Spermine Sildenafil Valproic acid Putrescine Pyridoxine phosphate N-Pyridoxyl-Glycine-5-Monophosphate L-Eflornithine N(6)-(pyridoxal phosphate)-L-lysine Geneticin Eflornithine
GWAS		Barrett's esophagus ( 27527254 ) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254 ) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872 ) Intracranial aneurysm ( 30823506 ) Obesity-related traits ( 23251661 ) Thyroid cancer (Papillary, radiation-related) ( 20350937 ) Zinc levels ( 26025379 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: APC BUB1 CDH1 CDKN2A DCC DLC1 FBXL17 FBXW7 MLH3 NEB ODC1 PIK3CA PRKAA2 TLR2 TMSB10 TPM3	17 interacting genes: BAAT CSNK2B GORASP2 HEMGN KAT5 MAP2K1 NANS OAZ1 OAZ2 RSC1A1 SSR1 STX17 TDRD7 TK1 TMOD1 TSTD2 ZNF510
Entrez ID		7111	4953
HPRD ID		01838	01324
Ensembl ID		ENSG00000136842	ENSG00000115758
Uniprot IDs		P28289	B4DXF8 P11926
PDB IDs		4PKG 4PKH 4PKI 4Z8G 4Z94 8F8T	1D7K 2ON3 2OO0 4ZGY 5BWA 7S3F 7S3G 7U6P 7U6U 9B8M 9B8N
GO Terms Enriched among Interactors		Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Regulation Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Gamma-catenin Binding Regulation Of Cytoskeleton Organization Apoptotic Process Negative Regulation Of Cell Development Cell Death Programmed Cell Death Negative Regulation Of Cytoskeleton Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Communication Negative Regulation Of Supramolecular Fiber Organization Catenin Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Cytosol Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Nervous System Development Regulation Of Organelle Organization Negative Regulation Of Cell Growth Negative Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell-matrix Adhesion Lamellipodium Sister Chromatid Cohesion Regulation Of Macroautophagy Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Cellular Response To Oxygen-containing Compound Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Protein Targeting To Mitochondrion Ligase Inhibitor Activity Supramolecular Fiber Organization Triacyl Lipopeptide Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Growth Negative Regulation Of Axonogenesis Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization	Ornithine Decarboxylase Inhibitor Activity Negative Regulation Of Polyamine Transmembrane Transport Viral Translational Frameshifting Polyamine Biosynthetic Process Polyamine Metabolic Process Negative Regulation Of Transmembrane Transport Golgi Organization Viral Process Amine Biosynthetic Process Biogenic Amine Biosynthetic Process