TMOD1 and TPM3

Number of citations of the paper that reports this interaction (PMID 10871039)
14

Data Source:
HPRD (in vitro)

		TMOD1	TPM3
Gene Name		tropomodulin 1	tropomyosin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Striated Muscle Thin Filament COP9 Signalosome Membrane Cortical Cytoskeleton	Stress Fiber Podosome Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Growth Cone Cortical Cytoskeleton Filamentous Actin Cleavage Furrow Extracellular Vesicular Exosome
	Molecular Function	Tropomyosin Binding Actin Filament Binding	Molecular_function Actin Binding
	Biological Process	Muscle Contraction Actin Filament Organization Adult Locomotory Behavior Muscle Filament Sliding Myofibril Assembly Pointed-end Actin Filament Capping	Movement Of Cell Or Subcellular Component Muscle Contraction Muscle Filament Sliding
Pathways		Striated Muscle Contraction	Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		4 interactors: NEB PRKAA2 TMSB10 TPM3	41 interactors: ACTA1 ACTB BLOC1S6 C1orf216 CCDC102B CCDC114 CCDC146 CCHCR1 CNN1 FAM9C FBXO5 HDDC3 HSF2 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 NEK2 OIP5 PBX3 S100A2 S100A4 SMAD3 SUMO4 SYCE1 TFPT THAP1 TLK1 TMOD1 TMOD2 TNNT1 TRAP1 TRIM27 TRIP6 VPS52 WASH3P
Entrez ID		7111	7170
HPRD ID		01838	01840
Ensembl ID		ENSG00000136842	ENSG00000143549
Uniprot IDs		P28289 Q5T7W3	B4DQ80 P06753 Q5VU58 Q5VU63 Q8TCG3
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Actin Filament-based Process Regulation Of Actin Filament Length Muscle Contraction Muscle System Process Regulation Of Cellular Component Size Carnitine Shuttle Regulation Of Actin Cytoskeleton Organization Somatic Muscle Development Sequestering Of Actin Monomers Regulation Of Actin Filament-based Process Carnitine Transmembrane Transport Regulation Of Energy Homeostasis Carnitine Transport Positive Regulation Of Glycolytic Process Fatty Acid Homeostasis Regulation Of Cytoskeleton Organization Quaternary Ammonium Group Transport Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of TOR Signaling Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Long-chain Fatty Acid Transport Histone Phosphorylation Ammonium Transmembrane Transport Sterol Biosynthetic Process Anion Homeostasis Regulation Of Organelle Organization	Actomyosin Structure Organization Organelle Organization Actin Filament-based Process Regulation Of Organelle Organization Cellular Component Assembly Actin-myosin Filament Sliding Muscle Filament Sliding Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Actin-mediated Cell Contraction Regulation Of Cytoskeleton Organization Actin Filament Organization Actin Filament-based Movement Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Pointed-end Actin Filament Capping Regulation Of Chromosome Segregation Regulation Of Actin Polymerization Or Depolymerization Myofibril Assembly Regulation Of Actin Filament Length Cell-cell Junction Organization Regulation Of Mitotic Cell Cycle Muscle Contraction Cell Division Cell Cycle Muscle System Process Organelle Assembly Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Cell Development Movement Of Cell Or Subcellular Component Mitotic Nuclear Division Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Regulation Of Muscle Contraction Positive Regulation Of Transcription Factor Import Into Nucleus Striated Muscle Cell Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Transforming Growth Factor Beta3 Production Inhibition Of APC-Cdc20 Complex Activity Regulation Of Metaphase Plate Congression Posterior Compartment Specification Anterior Compartment Pattern Formation Negative Regulation Of Cytoskeleton Organization Regulation Of Mitotic Sister Chromatid Separation Arp2/3 Complex-mediated Actin Nucleation Muscle Cell Development Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		assembly capping contractile contraction depolymerization ends filament leiomodins lmod1 lmod3 lmods localize locomotion myofibril myofibrillogenesis nucleators pointed redundantly rescued sarcomere structurally supplemented thin tmod4 tropomodulin unexpectedly uniformity xenopus	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next ntrk1 oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput transforming trk trka trkb trkc
Tagcloud (Difference) ?		assembly capping contractile contraction depolymerization ends filament leiomodins lmod1 lmod3 lmods localize locomotion myofibril myofibrillogenesis nucleators pointed redundantly rescued sarcomere structurally supplemented thin tmod4 tropomodulin unexpectedly uniformity xenopus	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next ntrk1 oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput transforming trk trka trkb trkc
Tagcloud (Intersection) ?