TMOD1 and TLR2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		TMOD1	TLR2
Description		tropomodulin 1	toll like receptor 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament COP9 Signalosome Membrane Myofibril Sarcomere Cortical Cytoskeleton	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft
	Molecular Function	Actin Binding Tropomyosin Binding	Lipopolysaccharide Binding Amyloid-beta Binding Lipopolysaccharide Immune Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Identical Protein Binding Peptidoglycan Binding Protein-containing Complex Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Muscle Contraction Actin Filament Organization Adult Locomotory Behavior Myofibril Assembly Pointed-end Actin Filament Capping Lens Fiber Cell Development	Toll-like Receptor Signaling Pathway Immune System Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction Learning Positive Regulation Of Gene Expression Microglia Development Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Negative Regulation Of Synapse Assembly Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Type II Interferon Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion
Pathways		Striated Muscle Contraction	ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Modulation by Mtb of host immune system SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions
Drugs			Lyme disease vaccine (recombinant OspA) Adapalene S-(Dimethylarsenic)Cysteine Golotimod Tuberculin purified protein derivative Pam2csk4
Diseases
GWAS		Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Intracranial aneurysm ( 30823506) Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937) Zinc levels ( 26025379)	Body fat mass ( 28552196)
Interacting Genes		16 interacting genes: APC BUB1 CDH1 CDKN2A DCC DLC1 FBXL17 FBXW7 MLH3 NEB ODC1 PIK3CA PRKAA2 TLR2 TMSB10 TPM3	29 interacting genes: AKT1 ANP32B CD14 EGFR FBP1 HEMGN HMGB1 HRAS HSP90B1 IRAK1 LY96 MAP2K1 MAPK8IP3 MYD88 NANS PIK3R1 RAC1 RIPK2 SMAD1 STX17 TGFB1 TICAM1 TIRAP TLR1 TLR10 TLR6 TMOD1 TOLLIP TRIP6
Entrez ID		7111	7097
HPRD ID		01838	04323
Ensembl ID		ENSG00000136842	ENSG00000137462
Uniprot IDs		P28289	A0A0S2Z4S4 B3KWR9 O60603
PDB IDs		4PKG 4PKH 4PKI 4Z8G 4Z94 8F8T	1FYW 1FYX 1O77 2Z7X 2Z80 6NIG 8AR0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Regulation Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Gamma-catenin Binding Regulation Of Cytoskeleton Organization Apoptotic Process Negative Regulation Of Cell Development Cell Death Programmed Cell Death Negative Regulation Of Cytoskeleton Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Communication Negative Regulation Of Supramolecular Fiber Organization Catenin Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Cytosol Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Nervous System Development Regulation Of Organelle Organization Negative Regulation Of Cell Growth Negative Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell-matrix Adhesion Lamellipodium Sister Chromatid Cohesion Regulation Of Macroautophagy Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Cellular Response To Oxygen-containing Compound Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Protein Targeting To Mitochondrion Ligase Inhibitor Activity Supramolecular Fiber Organization Triacyl Lipopeptide Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Growth Negative Regulation Of Axonogenesis Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization	Regulation Of Innate Immune Response Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Innate Immune Response Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Activation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Molecule Of Bacterial Origin Defense Response Immune Response-activating Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Cytokine Production Regulation Of Defense Response Immune Response-regulating Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Cellular Response To Bacterial Lipopeptide Toll-like Receptor 2 Binding Response To Lipid Response To Bacterial Lipoprotein Positive Regulation Of Gene Expression Innate Immune Response Regulation Of Cytokine Production Response To Stress Response To External Biotic Stimulus Regulation Of Immune System Process Response To Other Organism Defense Response To Symbiont Cellular Response To Lipid Immune Response Regulation Of Interleukin-6 Production Regulation Of Signal Transduction
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