TMOD1

Gene Name		tropomodulin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Striated Muscle Thin Filament COP9 Signalosome Membrane Cortical Cytoskeleton
	Molecular Function	Tropomyosin Binding Actin Filament Binding
	Biological Process	Muscle Contraction Actin Filament Organization Adult Locomotory Behavior Muscle Filament Sliding Myofibril Assembly Pointed-end Actin Filament Capping
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-protein Interactions		4 interactors: NEB PRKAA2 TMSB10 TPM3
Entrez ID		7111
HPRD ID		01838
Ensembl ID		ENSG00000136842
Uniprot IDs		P28289 Q5T7W3
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Actin Filament-based Process Regulation Of Actin Filament Length Muscle Contraction Muscle System Process Regulation Of Cellular Component Size Carnitine Shuttle Regulation Of Actin Cytoskeleton Organization Somatic Muscle Development Sequestering Of Actin Monomers Regulation Of Actin Filament-based Process Carnitine Transmembrane Transport Regulation Of Energy Homeostasis Carnitine Transport Positive Regulation Of Glycolytic Process Fatty Acid Homeostasis Regulation Of Cytoskeleton Organization Quaternary Ammonium Group Transport Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of TOR Signaling Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Long-chain Fatty Acid Transport Histone Phosphorylation Ammonium Transmembrane Transport Sterol Biosynthetic Process Anion Homeostasis Regulation Of Organelle Organization
Tagcloud ?		assembly capping contractile contraction depolymerization ends filament leiomodins lmod1 lmod3 lmods localize locomotion myofibril myofibrillogenesis nucleators pointed redundantly rescued sarcomere structurally supplemented thin tmod4 tropomodulin unexpectedly uniformity xenopus