KCNE1 and UBASH3A

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KCNE1	UBASH3A
Gene Name		potassium channel, voltage gated subfamily E regulatory beta subunit 1	ubiquitin associated and SH3 domain containing A
Image
Gene Ontology Annotations	Cellular Component	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Z Disc	Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Protein N-linked Glycosylation Protein O-linked Glycosylation Sensory Perception Of Sound Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Potassium Ion Export Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways
Drugs		Indapamide
Diseases
GWAS		Electrocardiographic traits ( 20062063)	Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 19430480 18840781) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)
Protein-Protein Interactions		6 interactors: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A	14 interactors: CBL CBS DAZAP2 KCNE1 KRT40 PARK2 REL SF3B4 SPRY2 TP53BP2 TRIM37 UBB UBC UBE2L3
Entrez ID		3753	53347
HPRD ID		01442	06904
Ensembl ID		ENSG00000180509	ENSG00000160185
Uniprot IDs		A7LFK2 A7LFK4 A8MWV9 C7S316 P15382 Q6FHJ6	P57075
PDB IDs		2K21	2CRN
Enriched GO Terms of Interacting Partners?		Regulation Of Muscle Contraction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Regulation Of Heart Contraction Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Muscle Contraction Cardiac Muscle Cell Action Potential Involved In Contraction Activation Of Adenylate Cyclase Activity Positive Regulation Of Potassium Ion Transport Muscle System Process Positive Regulation Of Adenylate Cyclase Activity Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Blood Circulation Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Positive Regulation Of Lyase Activity Cardiac Muscle Contraction Cellular Response To Drug Regulation Of Adenylate Cyclase Activity Regulation Of Potassium Ion Transport Positive Regulation Of CAMP Biosynthetic Process Heart Contraction Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Striated Muscle Contraction Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Striated Muscle Contraction Regulation Of CAMP Biosynthetic Process Potassium Ion Export Across Plasma Membrane Negative Regulation Of Potassium Ion Export Positive Regulation Of Dense Core Granule Biogenesis Regulation Of CAMP Metabolic Process Synaptic Transmission Regulation Of Ion Transport Regulation Of Cellular Component Movement Regulation Of Heart Rate By Hormone Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Histone H3-T6 Phosphorylation Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Ubiquitination I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Response To Organic Substance Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Transferase Activity Viral Protein Processing Positive Regulation Of Protein Metabolic Process Aggresome Assembly Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction By P53 Class Mediator Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Glycogen Biosynthetic Process Intracellular Transport Of Virus
Tagcloud ?		blockers channels coimmunoprecipitation contractions debate diversity electrophysiological exhibiting fail hek heteromers heterotetrameric heterotetramers kcne3 kv kv7 microdomains muscles myocytes oocyte photobleaching physiology raft shed smooth tune vasoconstriction vasorelaxants vessels
Tagcloud (Difference) ?		blockers channels coimmunoprecipitation contractions debate diversity electrophysiological exhibiting fail hek heteromers heterotetrameric heterotetramers kcne3 kv kv7 microdomains muscles myocytes oocyte photobleaching physiology raft shed smooth tune vasoconstriction vasorelaxants vessels
Tagcloud (Intersection) ?