KCNE1 and KCNH2

Number of citations of the paper that reports this interaction (PMID 9230439)
61

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		KCNE1	KCNH2
Gene Name		potassium channel, voltage gated subfamily E regulatory beta subunit 1	potassium channel, voltage gated eag related subfamily H, member 2
Image
Gene Ontology Annotations	Cellular Component	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Z Disc	Nuclear Envelope Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Phosphorelay Sensor Kinase Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Protein N-linked Glycosylation Protein O-linked Glycosylation Sensory Perception Of Sound Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Potassium Ion Export Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity	Phosphorelay Signal Transduction System Regulation Of Heart Rate By Hormone Synaptic Transmission Signal Transduction By Phosphorylation Cellular Response To Drug Regulation Of Membrane Potential Potassium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export
Pathways			Potassium Channels Voltage gated Potassium channels
Drugs		Indapamide	Dofetilide Amsacrine Ibutilide Terfenadine Prazosin Sotalol Doxazosin Cisapride Astemizole Verapamil Thioridazine Quinidine Pimozide Miconazole Amiodarone Carvedilol Terazosin Propafenone Halofantrine Dronedarone Sertindole
Diseases
GWAS		Electrocardiographic traits ( 20062063)	Electrocardiographic traits ( 20062061 20062063) QT interval ( 23166209 19305408 19305409)
Protein-Protein Interactions		6 interactors: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A	10 interactors: ALG10 ALG10B CDC73 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH
Entrez ID		3753	3757
HPRD ID		01442	01069
Ensembl ID		ENSG00000180509	ENSG00000055118
Uniprot IDs		A7LFK2 A7LFK4 A8MWV9 C7S316 P15382 Q6FHJ6	Q12809 Q15BH2
PDB IDs		2K21	1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 4HP9 4HQA
Enriched GO Terms of Interacting Partners?		Regulation Of Muscle Contraction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Regulation Of Heart Contraction Positive Regulation Of Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Muscle Contraction Cardiac Muscle Cell Action Potential Involved In Contraction Activation Of Adenylate Cyclase Activity Positive Regulation Of Potassium Ion Transport Muscle System Process Positive Regulation Of Adenylate Cyclase Activity Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Blood Circulation Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Positive Regulation Of Lyase Activity Cardiac Muscle Contraction Cellular Response To Drug Regulation Of Adenylate Cyclase Activity Regulation Of Potassium Ion Transport Positive Regulation Of CAMP Biosynthetic Process Heart Contraction Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Striated Muscle Contraction Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Striated Muscle Contraction Regulation Of CAMP Biosynthetic Process Potassium Ion Export Across Plasma Membrane Negative Regulation Of Potassium Ion Export Positive Regulation Of Dense Core Granule Biogenesis Regulation Of CAMP Metabolic Process Synaptic Transmission Regulation Of Ion Transport Regulation Of Cellular Component Movement Regulation Of Heart Rate By Hormone Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Histone H3-T6 Phosphorylation Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure	Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cardiac Conduction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Regulation Of Heart Rate Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Regulation Of Heart Contraction Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Striated Muscle Contraction Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein N-linked Glycosylation Ventricular Cardiac Muscle Cell Action Potential Regulation Of Muscle Contraction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Positive Regulation Of Intracellular Transport Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Transport Dolichol-linked Oligosaccharide Biosynthetic Process Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Protein Glycosylation Macromolecule Glycosylation Glycosylation Apoptotic Signaling Pathway Glucocorticoid Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Glycoprotein Biosynthetic Process Midbrain Development Carbohydrate Metabolic Process Regulation Of Intracellular Transport
Tagcloud ?		blockers channels coimmunoprecipitation contractions debate diversity electrophysiological exhibiting fail hek heteromers heterotetrameric heterotetramers kcne3 kv kv7 microdomains muscles myocytes oocyte photobleaching physiology raft shed smooth tune vasoconstriction vasorelaxants vessels	1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Difference) ?		blockers channels coimmunoprecipitation contractions debate diversity electrophysiological exhibiting fail hek heteromers heterotetrameric heterotetramers kcne3 kv kv7 microdomains muscles myocytes oocyte photobleaching physiology raft shed smooth tune vasoconstriction vasorelaxants vessels	1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Intersection) ?