KCNE1 and KCNJ15

Data Source: HiPPIP (Novel)

		KCNE1	KCNJ15
Name		potassium voltage-gated channel subfamily E regulatory subunit 1	potassium inwardly rectifying channel subfamily J member 15
Structure			No pdb structure
GO Annotations	Cellular Component	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Z Disc Monoatomic Ion Channel Complex Membrane Raft	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Epithelial Cell Maturation Monoatomic Ion Transport Potassium Ion Transport Sensory Perception Of Sound Vestibular Nucleus Development Secretory Granule Organization Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Heart Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Monoatomic Ion Transport Potassium Ion Transport Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Enflurane Promethazine Miconazole Azimilide	Ritodrine Yohimbine Butamben
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	None
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 20062063 ) Electrocardiographic traits (multivariate) ( 32602732 ) Hippocampal volume ( 29274321 ) L-selectin levels ( 25576479 ) Long QT syndrome ( 32429735 ) QT interval ( 24952745 29213071 30679814 31217584 )	A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 ) Non-response to antidepressants and depression ( 27622933 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		3 novel interactors: CBR3 KCNJ15 RCAN1	10 novel interactors: CBR3 CTSE DSCAM KCNE1 LRP8 MTCH1 SLC39A2 SON TOR1B TTC3
Interacting Genes		6 interacting genes: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A	6 interacting genes: IL16 KCNJ16 KCNJ2 KCNJ5 PATJ SNTA1
Entrez ID		3753	3772
HPRD ID		01442	03659
Ensembl ID		ENSG00000180509	ENSG00000157551
Uniprot IDs		A7LFK2 A7LFK4 C7S316 P15382 Q6FHJ6	Q99712
PDB IDs		2K21	Not available
GO Terms Enriched among Interactors		System Process Potassium Ion Import Across Plasma Membrane Muscle Contraction Muscle System Process Potassium Channel Activity Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Inorganic Cation Import Across Plasma Membrane Potassium Ion Export Across Plasma Membrane Adrenergic Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Membrane Repolarization During Action Potential Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Monoatomic Ion Channel Complex Renal Sodium Ion Absorption Inward Rectifier Potassium Channel Activity Renal Sodium Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Transport Membrane Repolarization Negative Regulation Of Potassium Ion Transport Regulation Of System Process Response To Mechanical Stimulus Positive Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Metal Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Potassium Ion Homeostasis Import Into Cell Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Muscle Contraction Renal Absorption Regulation Of Muscle System Process Cardiac Conduction Voltage-gated Potassium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Export Across Plasma Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Cognition Regulation Of Potassium Ion Transmembrane Transport	Regulation Of Monoatomic Ion Transport Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Inward Rectifier Potassium Channel Activity Membrane Repolarization Regulation Of Heart Rate Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Monoatomic Ion Channel Complex Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Cardiac Conduction Potassium Ion Transport Regulation Of Heart Contraction Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Blood Circulation Inorganic Cation Import Across Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Action Potential Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Metal Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Import Across Plasma Membrane Positive Regulation Of Potassium Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Kinesin Binding Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Ammon Gyrus Development Dendrite Morphogenesis Monoatomic Ion Transport Regulation Of System Process Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Potassium Ion Transmembrane Transport Vestibular Nucleus Development Regulation Of Monoatomic Cation Transmembrane Transport Relaxation Of Skeletal Muscle