KCNE1

Name	potassium voltage-gated channel subfamily E regulatory subunit 1
Structure
Novel Interactors	3 novel interactors: CBR3 KCNJ15 RCAN1
Interactors	6 interactors: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A
GO Annotations	Cellular Component	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Z Disc Monoatomic Ion Channel Complex Membrane Raft
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Epithelial Cell Maturation Monoatomic Ion Transport Potassium Ion Transport Sensory Perception Of Sound Vestibular Nucleus Development Secretory Granule Organization Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Heart Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs	Enflurane Promethazine Miconazole Azimilide
Diseases	Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 20062063 ) Electrocardiographic traits (multivariate) ( 32602732 ) Hippocampal volume ( 29274321 ) L-selectin levels ( 25576479 ) Long QT syndrome ( 32429735 ) QT interval ( 24952745 29213071 30679814 31217584 )
Entrez ID	3753
HPRD ID	01442
Ensembl ID	ENSG00000180509
Uniprot IDs	A7LFK2 A7LFK4 C7S316 P15382 Q6FHJ6
PDB IDs	2K21
GO Terms Enriched among Interactors ?	System Process Potassium Ion Import Across Plasma Membrane Muscle Contraction Muscle System Process Potassium Channel Activity Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Inorganic Cation Import Across Plasma Membrane Potassium Ion Export Across Plasma Membrane Adrenergic Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Membrane Repolarization During Action Potential Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Monoatomic Ion Channel Complex Renal Sodium Ion Absorption Inward Rectifier Potassium Channel Activity Renal Sodium Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Transport Membrane Repolarization Negative Regulation Of Potassium Ion Transport Regulation Of System Process Response To Mechanical Stimulus Positive Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Metal Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Potassium Ion Homeostasis Import Into Cell Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Muscle Contraction Renal Absorption Regulation Of Muscle System Process Cardiac Conduction Voltage-gated Potassium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Export Across Plasma Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Cognition Regulation Of Potassium Ion Transmembrane Transport